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Aliases KRT83, HB3, Hb-3, KRTHB3, keratin 83
External IDs MGI: 3690448 HomoloGene: 68248 GeneCards: KRT83
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 12: 52.31 – 52.32 Mb Chr 15: 101.49 – 101.49 Mb
PubMed search [1] [2]
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Keratin 83, also known as KRT83, is a protein which humans is encoded by the KRT83 gene.[3][4]


The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1 (KRT81), KRTHB3 (KRT83, this protein), and KRTHB6 (KRT86), is highly related. The other less-related subfamily includes KRTHB2 (KRT82), KRTHB4 (KRT84), and KRTHB5 (KRT85). All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB6, is found primarily in the hair cortex.[5]

Clinical significance[edit]

Mutations in the KRT83 gene have been associated with monilethrix.[6]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Rogers MA, Langbein L, Praetzel S, Moll I, Krieg T, Winter H, Schweizer J (February 1997). "Sequences and differential expression of three novel human type-II hair keratins". Differentiation. 61 (3): 187–94. PMID 9084137. doi:10.1046/j.1432-0436.1997.6130187.x. 
  4. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. PMC 2064177Freely accessible. PMID 16831889. doi:10.1083/jcb.200603161. 
  5. ^ "Entrez Gene: KRT83 keratin 83". 
  6. ^ van Steensel MA, Steijlen PM, Bladergroen RS, Vermeer M, van Geel M (March 2005). "A missense mutation in the type II hair keratin hHb3 is associated with monilethrix". J. Med. Genet. 42 (3): e19. PMC 1736019Freely accessible. PMID 15744029. doi:10.1136/jmg.2004.021030. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.