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Keratin 85, type II
Symbols KRT85 ; ECTD4; HB5; Hb-5; K85; KRTHB5; hHb5
External IDs OMIM602767 MGI1859268 HomoloGene37603 GeneCards: KRT85 Gene
RNA expression pattern
PBB GE KRT85 207670 at tn.png
More reference expression data
Species Human Mouse
Entrez 3891 406219
Ensembl ENSG00000135443 ENSMUSG00000047641
UniProt P78386 Q6IMF0
RefSeq (mRNA) NM_001300810 NM_001003668
RefSeq (protein) NP_001287739 NP_001003668
Location (UCSC) Chr 12:
52.36 – 52.37 Mb
Chr 15:
101.43 – 101.44 Mb
PubMed search [1] [2]

Keratin, type II cuticular Hb5 is a protein that in humans is encoded by the KRT85 gene.[1][2][3]

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5.[3]


  1. ^ Rogers MA, Langbein L, Praetzel S, Moll I, Krieg T, Winter H, Schweizer J (Apr 1997). "Sequences and differential expression of three novel human type-II hair keratins". Differentiation 61 (3): 187–94. doi:10.1046/j.1432-0436.1997.6130187.x. PMID 9084137. 
  2. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889. 
  3. ^ a b "Entrez Gene: KRT85 keratin 85". 

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