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Keratin 86, type II
Symbols KRT86 ; HB6; Hb1; KRTHB1; KRTHB6; MNX; hHb6
External IDs OMIM601928 MGI3690448 HomoloGene1717 GeneCards: KRT86 Gene
Species Human Mouse
Entrez 3892 16679
Ensembl ENSG00000170442 ENSMUSG00000067614
UniProt O43790 P97861
RefSeq (mRNA) NM_002284 NM_010667
RefSeq (protein) NP_002275 NP_034797
Location (UCSC) Chr 12:
52.25 – 52.31 Mb
Chr 15:
101.47 – 101.48 Mb
PubMed search [1] [2]

Keratin, type II cuticular Hb6 is a protein that in humans is encoded by the KRT86 gene.[1][2][3]

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix.[3]


  1. ^ Winter H, Rogers MA, Langbein L, Stevens HP, Leigh IM, Labreze C, Roul S, Taieb A, Krieg T, Schweizer J (Aug 1997). "Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix". Nat Genet 16 (4): 372–4. doi:10.1038/ng0897-372. PMID 9241275. 
  2. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889. 
  3. ^ a b "Entrez Gene: KRT86 keratin 86". 

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