In 1991, the national population census estimated the population of the district at about 81,500. The district had a population of approximately 131,700 in 2002, according to the national census that year, with an annual population growth rate of 4.3%. In 2012, it was estimated that the population of Kaberamaido District was approximately 199,200. The table below, illustrates how the district has grown between 2002 and 2012. All numbers are estimates.
Kaberamaido District is part of Teso sub-region and is the main area of the Kumam people. In 2008, the Kumam were in the majority, totaling 99,738 (74.7%) of the population. The Iteso were the next most populous group in the district, totaling 27,317 people (20.5%). These two ethnicities respectively, speak Kumam and Ateso languages and are of the Nilotic family. The Langi at 4,617 people (3.5%) are the next most populous group. The other tribal groups found in the district constitute less than 1% of the district population in individual tribal terms. These include, the Acholi, Bagwere, Bakenyi, Baruli, Mening, Basoga, Baganda and Alur.