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Kaine may refer to:
- Kaine (surname), including a list of people with the name
- Kaine (city), ancient name for Qena, a city in Upper Egypt
- Kaine (Laconia), an ancient town in Laconia, Greece
- Kaine (manga), a manga by Kaori Yuki
Persons with the given name
- Kaine Bennett Charleston (born 1983), Australian film producer and actor
- Kaine Harling (born 1977), Australian film producer and cameraman
- Kaine Manihera (born 1986), New Zealand rugby player
- Kaine Parker, fictional character in comic books that is a clone of Spider-Man
- Kaine Robertson (born 1980), New Zealand rugby player
| disambiguation page lists articles associated with the title Kaine.
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