Kallikrein 13

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Kallikrein 13
EC number3.4.21.119
CAS number342900-44-1
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum

Kallikrein 13 (EC, KLK13, kallikrein mK13, mGK-13, mK13, mKLK13, prorenin converting enzyme 1, PRECE-1, prorenin-converting enzyme, PRECE, proteinase P) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction

Hydrolyses mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg- pair in the N-terminus, to yield mature renin

This enzyme belongs in peptidase family S1A.


  1. ^ Nakayama K, Kim WS, Nakagawa T, Nagahama M, Murakami K (December 1990). "Substrate specificity of prorenin converting enzyme of mouse submandibular gland. Analysis using site-directed mutagenesis". The Journal of Biological Chemistry. 265 (34): 21027–31. PMID 2250008.
  2. ^ Kim WS, Hatsuzawa K, Ishizuka Y, Hashiba K, Murakami K, Nakayama K (April 1990). "A processing enzyme for prorenin in mouse submandibular gland. Purification and characterization". The Journal of Biological Chemistry. 265 (11): 5930–3. PMID 2180937.
  3. ^ Kikkawa Y, Yamanaka N, Tada J, Kanamori N, Tsumura K, Hosoi K (January 1998). "Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22)". Biochimica et Biophysica Acta. 1382 (1): 55–64. doi:10.1016/s0167-4838(97)00144-1. PMID 9507064.
  4. ^ Yao C, Karabasil MR, Purwanti N, Li X, Akamatsu T, Kanamori N, Hosoi K (March 2006). "Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice". The Journal of Biological Chemistry. 281 (12): 7968–76. doi:10.1074/jbc.m507705200. PMID 16423834.

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