Kamezaki Station was opened on March 1, 1886 as a passenger and freight station on the Japanese Government Railways (JGR). The JGR became the Japan National Railway (JNR) after World War II. Freight operations were discontinued from November 15, 1975 and small parcel operations from February 1, 1984. With the privatization and dissolution of the JNR on April 1, 1987, the station came under the control of the Central Japan Railway Company. Automatic turnstiles were installed in May 1992, and the TOICA system of magnetic fare cards was implemented in November 2006. The station building, dating from 1886 and rebuilt after a fire in 1895, is one of the oldest in Japan.