Kang Zhang

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Kang Zhang
Born
EducationM.D., Harvard University Medical School (1995)
Ph.D. (Genetics), Harvard University (1991)
Medical career
ProfessionOphthalmologist
InstitutionsUniversity of California, San Diego (Institute for Genomic Medicine)
Sub-specialtiesOphthalmic genetics
Stem cell research
Artificial intelligence
WebsiteKang Zhang Lab official page

Kang Zhang (Chinese: 张康[1]) is a Chinese-American ophthalmologist specializing in ophthalmic genetics and aging processes in the eye. He is currently Professor of Ophthalmology at the University of California, San Diego, and is also Founding Director of the Institute for Genomic Medicine at the University of California, San Diego. Zhang is particularly known for his work on lanosterol,[2] stem cell research (particularly limbal stem cells[3]), gene editing,[4] and artificial intelligence.[5]

Education[edit]

Born in Chengdu, Sichuan Province, China, Zhang obtained his B.S. in Biochemistry from Sichuan University in Chengdu, China in 1984. In 1991, Zhang graduated with a Ph.D. in Genetics from Harvard University. Subsequently, Zhang obtained his M.D. from a Harvard University Medical School and Massachusetts Institute of Technology Joint M.D. Program with magna cum laude honors in 1995.[6]

Career[edit]

After completing an ophthalmology residency at the Wilmer Eye Institute at Johns Hopkins University, Zhang became Assistant Staff at the Cole Eye Institute at the Cleveland Clinic Foundation. Zhang completed a retina fellowship at the University of Utah, and afterwards became Assistant Professor at the University of Utah from 2002-2006.

In 2013, Zhang, along with Trey Ideker, identified that the molecular aging clock could be measured by blood and tissues, and made use of epigenetic markers.[7]

In 2014, Zhang, along with Yizhi Liu and Xiangdong Fu, investigated mechanisms and developed a new method of limbal stem cell repair and regeneration.[3] Zhang has also pioneered the usage of artificial intelligence in diagnosing eye diseases.[8]

In 2015, Zhang discovered that lanosterol can be used in eyedrop form to help prevent cataracts.[2][9]

Awards[edit]

Some of Kang Zhang's selected awards are listed below.[6]

Professional affiliations[edit]

Professional affiliations:[6]

Selected publications[edit]

To date, Zhang has published more than 150 papers. Some selected publications are listed below.[10]

  • Vasireddy V, Jablonski MM, Khan NW, Wang XF, Sahu P, Sparrow JR, Ayyagari R (December 2009). "Elovl4 5-bp deletion knock-in mouse model for Stargardt-like macular degeneration demonstrates accumulation of ELOVL4 and lipofuscin". Exp. Eye Res. 89 (6): 905–12. doi:10.1016/j.exer.2009.07.021. PMC 2783393. PMID 19682985.
  • Yang Z, Camp NJ, Sun H, Tong Z, Gibbs D, Cameron DJ, Chen H, Zhao Y, Pearson E, Li X, Chien J, Dewan A, Harmon J, Bernstein PS, Shridhar V, Zabriskie NA, Hoh J, Howes K, Zhang K (November 2006). "A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration". Science. 314 (5801): 992–3. doi:10.1126/science.1133811. PMID 17053109.
  • Hannum G, Guinney J, Zhao L, Zhang L, Hughes G, Sadda S, Klotzle B, Bibikova M, Fan JB, Gao Y, Deconde R, Chen M, Rajapakse I, Friend S, Ideker T, Zhang K (January 2013). "Genome-wide methylation profiles reveal quantitative views of human aging rates". Mol. Cell. 49 (2): 359–367. doi:10.1016/j.molcel.2012.10.016. PMC 3780611. PMID 23177740.
  • Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng Z, Zhao L, Peyman G, Ouyang H, Jiang W, Zhao J, Chen X, Zhang L, Wang CY, Bastian BC, Zhang K, Guan KL (June 2014). "Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP". Cancer Cell. 25 (6): 822–30. doi:10.1016/j.ccr.2014.04.017. PMC 4075337. PMID 24882516.
  • Liao C, Yin AH, Peng CF, Fu F, Yang JX, Li R, Chen YY, Luo DH, Zhang YL, Ou YM, Li J, Wu J, Mai MQ, Hou R, Wu F, Luo H, Li DZ, Liu HL, Zhang XZ, Zhang K (May 2014). "Noninvasive prenatal diagnosis of common aneuploidies by semiconductor sequencing". Proc. Natl. Acad. Sci. U.S.A. 111 (20): 7415–20. doi:10.1073/pnas.1321997111. PMC 4034209. PMID 24799683.
  • Ouyang H, Xue Y, Lin Y, Zhang X, Xi L, Patel S, Cai H, Luo J, Zhang M, Zhang M, Yang Y, Li G, Li H, Jiang W, Yeh E, Lin J, Pei M, Zhu J, Cao G, Zhang L, Yu B, Chen S, Fu XD, Liu Y, Zhang K (July 2014). "WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis". Nature. 511 (7509): 358–61. doi:10.1038/nature13465. PMC 4610745. PMID 25030175.
  • Bhisitkul RB, Mendes TS, Rofagha S, Enanoria W, Boyer DS, Sadda SR, Zhang K (May 2015). "Macular atrophy progression and 7-year vision outcomes in subjects from the ANCHOR, MARINA, and HORIZON studies: the SEVEN-UP study". Am. J. Ophthalmol. 159 (5): 915–24.e2. doi:10.1016/j.ajo.2015.01.032. PMID 25640411.
  • Zhao L, Chen XJ, Zhu J, Xi YB, Yang X, Hu LD, Ouyang H, Patel SH, Jin X, Lin D, Wu F, Flagg K, Cai H, Li G, Cao G, Lin Y, Chen D, Wen C, Chung C, Wang Y, Qiu A, Yeh E, Wang W, Hu X, Grob S, Abagyan R, Su Z, Tjondro HC, Zhao XJ, Luo H, Hou R, Jefferson J, Perry P, Gao W, Kozak I, Granet D, Li Y, Sun X, Wang J, Zhang L, Liu Y, Yan YB, Zhang K (July 2015). "Lanosterol reverses protein aggregation in cataracts". Nature. 523 (7562): 607–11. doi:10.1038/nature14650. PMID 26200341.
  • Hu CM, Fang RH, Wang KC, Luk BT, Thamphiwatana S, Dehaini D, Nguyen P, Angsantikul P, Wen CH, Kroll AV, Carpenter C, Ramesh M, Qu V, Patel SH, Zhu J, Shi W, Hofman FM, Chen TC, Gao W, Zhang K, Chien S, Zhang L (October 2015). "Nanoparticle biointerfacing by platelet membrane cloaking". Nature. 526 (7571): 118–21. doi:10.1038/nature15373. PMC 4871317. PMID 26374997.
  • Skowronska-Krawczyk D, Zhao L, Zhu J, Weinreb RN, Cao G, Luo J, Flagg K, Patel S, Wen C, Krupa M, Luo H, Ouyang H, Lin D, Wang W, Li G, Xu Y, Li O, Chung C, Yeh E, Jafari M, Ai M, Zhong Z, Shi W, Zheng L, Krawczyk M, Chen D, Shi C, Zin C, Zhu J, Mellon PL, Gao W, Abagyan R, Zhang L, Sun X, Zhong S, Zhuo Y, Rosenfeld MG, Liu Y, Zhang K (September 2015). "P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma". Mol. Cell. 59 (6): 931–40. doi:10.1016/j.molcel.2015.07.027. PMC 4648709. PMID 26365380.
  • Liu Y, Wu F, Lu L, Lin D, Zhang K (August 2015). "Videos in Clinical Medicine: Examination of the Retina". N. Engl. J. Med. 373 (8): e9. doi:10.1056/NEJMvcm1308125. PMID 26287871.
  • Lin H, Ouyang H, Zhu J, Huang S, Liu Z, Chen S, Cao G, Li G, Signer RA, Xu Y, Chung C, Zhang Y, Lin D, Patel S, Wu F, Cai H, Hou J, Wen C, Jafari M, Liu X, Luo L, Zhu J, Qiu A, Hou R, Chen B, Chen J, Granet D, Heichel C, Shang F, Li X, Krawczyk M, Skowronska-Krawczyk D, Wang Y, Shi W, Chen D, Zhong Z, Zhong S, Zhang L, Chen S, Morrison SJ, Maas RL, Zhang K, Liu Y (March 2016). "Lens regeneration using endogenous stem cells with gain of visual function". Nature. 531 (7594): 323–8. doi:10.1038/nature17181. PMC 6061995. PMID 26958831.
  • Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, Jafari M, Esteban CR, Berggren WT, Lajara J, Nuñez-Delicado E, Guillen P, Campistol JM, Matsuzaki F, Liu GH, Magistretti P, Zhang K, Callaway EM, Zhang K, Belmonte JC (December 2016). "In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration". Nature. 540 (7631): 144–149. doi:10.1038/nature20565. PMC 5331785. PMID 27851729.
  • Hao X, Luo H, Krawczyk M, Wei W, Wang W, Wang J, Flagg K, Hou J, Zhang H, Yi S, Jafari M, Lin D, Chung C, Caughey BA, Li G, Dhar D, Shi W, Zheng L, Hou R, Zhu J, Zhao L, Fu X, Zhang E, Zhang C, Zhu JK, Karin M, Xu RH, Zhang K (July 2017). "DNA methylation markers for diagnosis and prognosis of common cancers". Proc. Natl. Acad. Sci. U.S.A. 114 (28): 7414–7419. doi:10.1073/pnas.1703577114. PMC 5514741. PMID 28652331.
  • Xu RH, Wei W, Krawczyk M, Wang W, Luo H, Flagg K, Yi S, Shi W, Quan Q, Li K, Zheng L, Zhang H, Caughey BA, Zhao Q, Hou J, Zhang R, Xu Y, Cai H, Li G, Hou R, Zhong Z, Lin D, Fu X, Zhu J, Duan Y, Yu M, Ying B, Zhang W, Wang J, Zhang E, Zhang C, Li O, Guo R, Carter H, Zhu JK, Hao X, Zhang K (November 2017). "Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma". Nat Mater. 16 (11): 1155–1161. doi:10.1038/nmat4997. PMID 29035356.
  • Zhu J, Ming C, Fu X, Duan Y, Hoang DA, Rutgard J, Zhang R, Wang W, Hou R, Zhang D, Zhang E, Zhang C, Hao X, Xiong W, Zhang K (June 2017). "Gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors". Cell Res. 27 (6): 830–833. doi:10.1038/cr.2017.57. PMC 5518875. PMID 28429769.
  • Kermany DS, Goldbaum M, Cai W, Valentim C, Liang H, Baxter SL, McKeown A, Yang G, Wu X, Yan F, Dong J, Prasadha MK, Pei J, Ting M, Zhu J, Li C, Hewett S, Dong J, Ziyar I, Shi A, Zhang R, Zheng L, Hou R, Shi W, Fu X, Duan Y, Huu V, Wen C, Zhang ED, Zhang CL, Li O, Wang X, Singer MA, Sun X, Xu J, Tafreshi A, Lewis MA, Xia H, Zhang K (February 2018). "Identifying Medical Diagnoses and Treatable Diseases by Image-Based Deep Learning". Cell. 172 (5): 1122–1131.e9. doi:10.1016/j.cell.2018.02.010. PMID 29474911.
  • Liang H, Tsui BY, Ni H, Valentim C, Baxter SL, Liu G, Cai W, Kermany DS, Sun X, Chen J, He L, Zhu J, Tian P, Shao H, Zheng L, Hou R, Hewett S, Li G, Liang P, Zang X, Zhang Z, Pan L, Cai H, Ling R, Li S, Cui Y, Tang S, Ye H, Huang X, He W, Liang W, Zhang Q, Jiang J, Yu W, Gao J, Ou W, Deng Y, Hou Q, Wang B, Yao C, Liang Y, Zhang S, Duan Y, Zhang R, Gibson S, Zhang CL, Li O, Zhang ED, Karin G, Nguyen N, Wu X, Wen C, Xu J, Xu W, Wang B, Wang W, Li J, Pizzato B, Bao C, Xiang D, He W, He S, Zhou Y, Haw W, Goldbaum M, Tremoulet A, Hsu CN, Carter H, Zhu L, Zhang K, Xia H (March 2019). "Evaluation and accurate diagnoses of pediatric diseases using artificial intelligence". Nat. Med. 25 (3): 433–438. doi:10.1038/s41591-018-0335-9. PMID 30742121.
  • Lu Y, Zhang K (March 2018). "Cellular Reprogramming in the Retina - Seeing the Light". N. Engl. J. Med. 378 (11): 1059–1060. doi:10.1056/NEJMcibr1713887. PMID 29539280.
  • Xia, H., Li, X., Gao, W., Fu, X., Fang, FR., Zhang, L., and Zhang, K. (2018). Tissue repair and regeneration with endogenous stem cells. Nature Review Materials, 3:174-193 doi:10.1038/s41578-018-0027-6
  • He J, Baxter SL, Xu J, Xu J, Zhou X, Zhang K (January 2019). "The practical implementation of artificial intelligence technologies in medicine". Nat. Med. 25 (1): 30–36. doi:10.1038/s41591-018-0307-0. PMID 30617336.

References[edit]

  1. ^ Kang Zhang profile (jyyxylc.com)
  2. ^ a b Brown, Eryn (Jul 22, 2015). "Genetics study points toward eyedrop treatment for cataracts". Los Angeles Times. Retrieved Apr 23, 2019.
  3. ^ a b Ouyang H, Xue Y, Lin Y, Zhang X, Xi L, Patel S, Cai H, Luo J, Zhang M, Zhang M, Yang Y, Li G, Li H, Jiang W, Yeh E, Lin J, Pei M, Zhu J, Cao G, Zhang L, Yu B, Chen S, Fu XD, Liu Y, Zhang K (July 2014). "WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis". Nature. 511 (7509): 358–61. doi:10.1038/nature13465. PMC 4610745. PMID 25030175.
  4. ^ Zhu J, Ming C, Fu X, Duan Y, Hoang DA, Rutgard J, Zhang R, Wang W, Hou R, Zhang D, Zhang E, Zhang C, Hao X, Xiong W, Zhang K (June 2017). "Gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors". Cell Res. 27 (6): 830–833. doi:10.1038/cr.2017.57. PMC 5518875. PMID 28429769.
  5. ^ Kermany DS, Goldbaum M, Cai W, Valentim C, Liang H, Baxter SL, McKeown A, Yang G, Wu X, Yan F, Dong J, Prasadha MK, Pei J, Ting M, Zhu J, Li C, Hewett S, Dong J, Ziyar I, Shi A, Zhang R, Zheng L, Hou R, Shi W, Fu X, Duan Y, Huu V, Wen C, Zhang ED, Zhang CL, Li O, Wang X, Singer MA, Sun X, Xu J, Tafreshi A, Lewis MA, Xia H, Zhang K (February 2018). "Identifying Medical Diagnoses and Treatable Diseases by Image-Based Deep Learning". Cell. 172 (5): 1122–1131.e9. doi:10.1016/j.cell.2018.02.010. PMID 29474911.
  6. ^ a b c Kang Zhang awards and publications
  7. ^ Stipp, David (Jul 22, 2013). "Searching for Meaningful Markers of Aging". New York Times. Retrieved Apr 23, 2019.
  8. ^ Fikes, Bradley J. (Feb 26, 2018). "Serious eye diseases accurately diagnosed through artificial intelligence". San Diego Union-Tribune. Retrieved Apr 23, 2019.
  9. ^ Ling Zhao; Xiang-Jun Chen; Jie Zhu; Yi-Bo Xi; Xu Yang; Li-Dan Hu; Hong Ouyang; Sherrina H. Patel; Xin Jin; Danni Lin; Frances Wu; Ken Flagg; Huimin Cai; Gen Li; Guiqun Cao; Ying Lin; Daniel Chen; Cindy Wen; Christopher Chung; Yandong Wang; Austin Qiu; Emily Yeh; Wenqiu Wang; Xun Hu; Seanna Grob; et al. (July 2015). "Lanosterol reverses protein aggregation in cataracts". Nature. 523 (7562): 607–611. doi:10.1038/nature14650. PMID 26200341.
  10. ^ Kang Zhang publications on PubMed

External links[edit]