Karel Styblo

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Karel Styblo

Karel Styblo, MD, (1921 – 13 March 1998) was born in Czechoslovakia.[1] Internationally renowned for his work with tuberculosis (TB),[2] he was a medical advisor to the Royal Netherlands Tuberculosis Association, and a director of the International Union Against Tuberculosis and Lung Disease (IUATLD) in Paris from 1979.[1] He is known as the "father of modern TB epidemiology"[3] and the "father of modern TB control".[4]

Personal life[edit]

Styblo was born in Klaster, Czechoslovakia in 1921.[1] Toward the end of World War II, he was imprisoned at the Mauthausen-Gusen concentration camp in Austria, where he contracted tuberculosis.[2] After his recovery and release, Styblo entered Charles University in Prague. During his medical studies the tuberculosis infection acquired in Mauthausen reactivated and he was admitted and treated at Bulovka Hospital in Prague from October 1948 till April 1950.[5] After earning his medical degree in 1950, he returned to Bulovka Hospital to become a chest physician, followed by five years of postgraduate study at the Tuberculosis Research Institute.[citation needed] Obituaries say Styblo studied under Sir John Crofton at the University of Edinburgh, Scotland in the 1950s;[1][2] the IUATLD says Crofton and Styblo worked together in Edinburgh in the early 50s.[6] Crofton said in an interview that they met in 1960 while Styblo was still in Czechoslovakia.[7] Of Styblo, Crofton said:

He was a quiet man, but wonderfully persistent and an enormous worker. Several east African countries had asked for help with tuberculosis and Styblo was sent there. He proved to have a genius for persuading governments that tuberculosis was a major economic problem as well as a public health concern. He was also able to convince them that they could handle diagnosis and treatment through their routine health services, without special tuberculosis clinics and services. Above all he stressed the importance of monitoring patients throughout the course of treatment, as he had seen done in Edinburgh.[7]

Styblo moved to the Netherlands after the unsuccessful Prague Spring,[8] and became a Dutch citizen in 1971.[1] He was still active when he died suddenly on 13 March 1998 at the age of 76;[2] his wife, Lida, predeceased him.[1]


Styblo's life's work was to develop, pioneer, and demonstrate the "proof of principle" for the strategy used to control TB by the World Bank and promulgated by the World Health Organization (WHO).[9] Called Directly Observed Therapy – Short Course (DOTS),[10] the TB therapy revolutionized the fight to control TB throughout the world.[11][12] DOTS has been employed by 187 of the 193 members of WHO as of 2008.[9] Styblo applied this methodology to the national TB control programs of Tanzania, Benin, Malawi, Mozambique, Nicaragua,[1] and China;[9] DOTS has been described as the "most effective means of controlling the current tuberculosis epidemic" and had been applied in over 90 countries as of 2001.[12]

In a historical review of tuberculosis, Murray (2004) writes:

In the mid-1970s, a redoubtable Czech, Karel Styblo, harnessed the meager resources of the International Union against Tuberculosis and Lung Disease and showed that, contrary to expert opinion, tuberculosis could be controlled in extremely poor countries: beginning in Tanzania, one of the poorest of them all.[11]

According to the World Health Organization:

The role of Dr Karel Styblo, IUAT Scientific Director, in the development of these innovative programmes cannot be understated. He combined an astonishing knowledge of the epidemiology of TB with a remarkable understanding of the management principles of TB control and a tenacious commitment to excellence in his work. His contribution to TB was immense, and he will go down in history as the father of modern TB control and one of the heroes of public health of the 20th century. The principles developed by him in Africa were later adapted and promoted by WHO as DOTS, and adopted in places as diverse as China, New York, and India.[4]

Styblo was responsible for a guiding epidemiological rule of thumb for TB known as "Styblo's rule", which stated that "an annual incidence of 50 sputum-smear-positive TB cases in a population of 100,000 generates an annual risk of infection of 1%" (the rule is no longer used to estimate prevalence of TB).[13] He was also responsible for instituting a systematic feedback method for analyzing outcomes of TB cases, known as the "cohort review" principle (CR), which was adopted in London and outside of the UK.[14]


Styblo was a recipient of a 1982 Gold Medal award of the Robert Koch Prizes.[15] The International Union Against Tuberculosis and Lung Diseases (IUATLD) instituted the Karel Styblo Public Health Prize after his death,[12][16] to recognize a "health worker (physician or lay-person) or a community organisation for contributions to tuberculosis control or lung health over a period of 10 years or more".[16][17]


  1. ^ a b c d e f g Walton, John (5 December 1998). "Karel Styblo". BMJ. 317 (7171): 1596. doi:10.1136/bmj.317.7172.1596. PMC 1114410Freely accessible. PMID 9836685. 
  2. ^ a b c d "Partners forum: 50-50" (PDF). Stop TB Partnership. World Health Organization. 2001. Retrieved 28 March 2012. 
  3. ^ Migliori GB, D'Ambrosio L, Centis R (June 2011). "Tuberculosis: an ancient and evergreen disease" (PDF). Eur Respir Rev. 20 (120): 69–70. doi:10.1183/09059180.00003311. PMID 21632794. 
  4. ^ a b "Chapter 2: When worlds collide: the power and potential of DOTS". The Global Plan to Stop TB (2000 - 2005) (PDF). World Health Organization. 2002. Retrieved 28 March 2012.  (see also the 2011 - 2015 version)
  5. ^ Personal correspondence with son Charles Styblo, September 2012 - Information based on original Czech documents kindly provided and translated by his son Charles Styblo who lives in The Netherlands. Original copies of these documents are in Jaap F. Broekmans' possession.
  6. ^ "History of The Union". International Union Against Tuberculosis and Lung Disease. Retrieved 30 March 2012. 
  7. ^ a b Sir John Crofton (December 2009). "Fighting resistance". Bull. World Health Organ. 87 (12): 894–5. doi:10.2471/BLT.09.051209. PMC 2789371Freely accessible. PMID 20454479. 
  8. ^ "Newsletter from Kiyose". The Research Institute of Tuberculosis, Japan. October 1998. Retrieved 28 March 2012. 
  9. ^ a b c Obermeyer Z, Abbott-Klafter J, Murray CJ (2008). "Has the DOTS strategy improved case finding or treatment success? An empirical assessment". PLoS ONE. 3 (3): e1721. doi:10.1371/journal.pone.0001721. PMC 2253827Freely accessible. PMID 18320042.  open access publication – free to read
  10. ^ "News in brief". The Lancet. 351 (9106): 890. 21 March 1998. doi:10.1016/S0140-6736(05)70308-1. 
  11. ^ a b Murray JF (June 2004). "A century of tuberculosis". Am. J. Respir. Crit. Care Med. 169 (11): 1181–6. doi:10.1164/rccm.200402-140OE. PMID 15161611. 
  12. ^ a b c "TDR co-worker awarded for contribution to TB control" (PDF). World Health Organization. October 2001. Retrieved 28 March 2012. 
  13. ^ Dye, Christopher (2008). "Breaking a law: tuberculosis disobeys Styblo's rule" (PDF). Bull. World Health Organ. [online]. 86 (1): 4. doi:10.2471/blt.07.049510. ISSN 0042-9686. 
  14. ^ "P61 Karel Styblo comes to town: staff perspectives on TB cohort review". Thorax. 66: A93. 2011. doi:10.1136/thoraxjnl-2011-201054c.61. 
  15. ^ "Holders of the Robert Koch Gold Medal". Robert Koch Foundation. Retrieved 28 March 2012. 
  16. ^ a b "About the Union Awards". International Union against Tuberculosis and Lung Disease. Retrieved 28 March 2012. 
  17. ^ "International Union Against Tuberculosis and Lung Disease (The Union)". RDInfo. 2010. Retrieved 28 March 2012. 

Further reading[edit]