Kate Molale (2 January 1928 – 9 May 1980) was a South African political activist.
She joined the African National Congress Sophiatown branch in the early 1950s. In 1954 she was elected as secretary of the Sophiatown ANC branch. She was an activist in the popular resistance against the forced eviction of the Sophiatown residents. She mobilized people against the 1953 Bantu Education Act, organizing pioneers (Masupatsela) to bolster the school boycotts in protest against the Bantu Education Act. Under her leadership many children were mobilized for school boycotts in Sophiatown, Orlando, Brakpan, Randfontein and Alexandra.
In 1955 Molale was part of a delegation that went to the Native Commissioner in Johannesburg to deliver a protest against the extension of pass laws to include African women. As the delegation left the Native Commissioner's office, they were detained and charged. Molale was one of the key activists in mobilizing women during the 9 August 1956 Anti-pass campaign, travelling to various corners of the country on agitation tours.
Molale was one of the ANC activists targeted at the time of the launching of 90 days detention without trial. After being released from detention, she went underground and became a commander of Umkhonto we Sizwe.
Between 1970 and 1975 Molale represented the ANC Women's League/Women's Section in the Women's International Democratic Federation. After leaving the WIDF office, Molale based herself in Morogoro, Tanzania. In Tanzania she dedicated herself to the care of children of exiled South African activists. Molale suffered a traffic accident in Tanzania on 3 May 1980. Whilst co-traveller Peter Sithole died immediately, Molale passed into coma. She was pronounced dead on 9 May 1980.