Seelye graduated from Amherst College in 1984. In addition to reporting, she has been employed by the Middle East Institute, Queen Noor of Jordan and as Manager of Media Relations for the American-Arab Anti-Discrimination Committee. In 2004, Seelye received an honorary doctorate () from Amherst College and is also a Fulbright Scholar ().
Seelye is a daughter of Talcott W. Seelye (1922–2006), a former U.S. ambassador to Tunisia and Syria, and Joan Hazeltine. Seelye is a descendent of former Amherst College president Julius H. Seelye.
- PBS Frontline "Syria: Beyond the Axis of Evil?" (October 24, 2008)
- PBS Frontline Palestinian Territories: "Inside Hamas" (May 9, 2006)
- PBS Frontline Syria: "U.N. Murder Investigation Closes in on Syria" (September 21, 2005)
- PBS Frontline Lebanon: "The Earthquake" (May 17, 2005)
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