Afrasiabi is a former consultant to the United Nations "Dialogue Among Civilizations", for which he interviewed the former Iranian president, Mohammad Khatami. Afrasiabi is a member of the advisory board of the Campaign Against Sanctions and Military Intervention in Iran. Afrasiabi has authored numerous articles in scholarly journals and newspapers, including Harvard Theological Review, Harvard International Review, UN Chronicle, Boston Globe, Global Dialogue, Middle East Journal, Mediterranean Affairs, Brown's Journal of World Affairs, International Herald Tribune, Der Tageszeit, Der Tagesspiegel, Journal of International Affairs, Telos, Nation Magazine, Asia times, Washington Post, San Francisco Chronicle, Monthly Review, as well as dozens of articles and letters in The New York Times. Afrasiabi has made dozens of television appearances as a Middle East expert on CNN, Aljazeera, Voice of America, PBS, BBC, PressTV, Russia Today, and other networks. Afrasiabi is fluent in several languages and has published in Farsi, English, German, French, and Spanish.
From 1996 to 2003, Afrasiabi was involved in a legal conflict with Roy Mottahedeh, former director of the Center for Middle Eastern Studies at Harvard University, who had been his superior during Afrasiabi's time as a postdoctoral fellow at Harvard, and Harvard University itself. The conflict started with an alleged extortion against Mottahedeh's subordinates and a "pre-dawn" arrest of Afrasiabi by Harvard police, and terminated in 2003 with a civil rights case against Harvard, Mottahedeh and the Supreme Court of the United States, in which Afrasiabi acted as his own attorney. During associated controversies, Afrasiabi was supported by Mike Wallace of the US television program 60 Minutes, author David Mamet, linguist Noam Chomsky and political scientist Howard Zinn, and former deputy prime minister of Iran, Farhang Mehr. In a video deposition, Wallace has defended Afrasiabi and accused professor Mottahedeh of making false statements to him about Afrasiabi. His "David and Goliath" battle with Harvard has been praised by Mike Wallace, who has stated "I admire Dr. Afrasiabi. He has been wronged. The cannons of Harvard are lined up against a pea shooter."