In the 2008–09 season, he signed with another Italian team Virtus Bologna. With Virtus, he won Europe's third-tier basketball clubs competition, the EuroChallenge championship, and he was named the MVP of the Final Four.
In March 2011, he signed a four-year contract extension with Khimki, worth a guaranteed $9 million in net income (after taxes). In September 2011, however, Khimki announced that they would be dissolving his contract, after he struggled to bounce back from injuries.
In July 2012 he signed a two-year deal with Emporio Armani Milano worth 2.5M euros. In his second season with the team, he led Milano to the Euroleague playoff series against Maccabi Tel Aviv. Milan had the homecourt advantage, and hosted the first two games of the series. Milan led by 12 points with about 2 minutes remaining in game 1, but Maccabi was able to tie the score few seconds before the buzzer. Langford had a chance to win the game from the foul line, but missed a crucial free throw, and the game went to overtime. Maccabi have won 99-101 in a game which is considered one of the best in the club's history. Maccabi won the series 1-3, despite 28 points of Langord in game 4 in Tel Aviv. Langord led the Euroleague with 17.6 points per game. In May 2014, he was awarded with the Alphonso Ford Trophy, an annual award given to the Euroleague's top scorer of the season. He was also named to the All-Euroleague First Team of the Euroleague. Langford led Milano to the Italian League title, for the first time since 1996.
Langford has two brothers who are also basketball players. His brother Kevin played in college for Texas Christian University and has played professionally in Europe. Langford's other brother, Justin Wesley, played for the Kansas Jayhawks.