Kenneth B. Storey

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Kenneth Storey
Kenneth Storey in his lab.jpg
Born
Kenneth Bruce Storey

(1949-10-23) October 23, 1949 (age 69)
Taber, Alberta, Canada
ResidenceOttawa, Ontario, Canada
CitizenshipCanadian
AwardsRoyal Society of Canada Fellow (1990)
Flavelle Medal (2010)
Fry Medal (2011)
Cryo-Fellow (2012)
Scientific career
FieldsMolecular Physiology
Biochemistry
Biochemical Adaptation
InstitutionsCarleton University, Canada
Doctoral advisorPeter Hochachka
Notable studentsCurrent Students Past Students

Kenneth B. Storey, Ph.D. FRSC (born October 23, 1949) is a Canadian scientist whose work draws from a variety of fields including biochemistry and molecular biology. He is a Professor of Biology, Biochemistry and Chemistry at Carleton University in Ottawa, Canada. Storey has a world-wide reputation for his research on biochemical adaptation - the molecular mechanisms that allow animals to adapt to and endure severe environmental stresses such as deep cold, oxygen deprivation, and desiccation.[1]

Biography[edit]

Kenneth Storey studied biochemistry at the University of Calgary (B.Sc. '71) and zoology at the University of British Columbia (Ph.D. '74).[2][3] Storey is a Professor of Biochemistry, cross-appointed in the Departments of Biology, Chemistry and Neuroscience and holds the Canada Research Chair in Molecular Physiology at Carleton University in Ottawa, Canada.[4]

Storey is an elected fellow of the Royal Society of Canada,[5] of the Society for Cryobiology[6] and of the American Association for the Advancement of Science. He has won fellowships and awards for research excellence including the Fry medal from the Canadian Society of Zoologists (2011), the Flavelle medal from the Royal Society of Canada (2010), Ottawa Life Sciences Council Basic Research Award (1998), a Killam Senior Research Fellowship (1993–1995), the Ayerst Award from the Canadian Society for Molecular Biosciences (1989), an E.W.R. Steacie Memorial Fellowship from the Natural Sciences and Engineering Research Council of Canada (1984–1986), and four Carleton University Research Achievement Awards. Storey is the author of over 844 research articles, the editor of seven books, has given over 500 talks at conferences and institutes worldwide, and organized numerous international symposia.[7]

Research[edit]

Storey is one of the most cited researchers in the world.[8] Storey's research includes studies of enzyme properties, gene expression, protein phosphorylation, and cellular signal transduction mechanisms to seek out the basic principles of how organisms endure and flourish under extreme conditions. He is particularly known within the field of cryobiology for his studies of animals that can survive freezing, especially the frozen "frog-sicles" (Rana sylvatica) that have made his work popular with multiple TV shows and magazines.[9][10][11] Storey's studies of the adaptations that allow frogs, insects, and other animals to survive freezing have made major advances in the understanding of how cells, tissues and organs can endure freezing.[11] Storey was also responsible for the discovery that some turtle species are freeze tolerant: newly hatched painted turtles that spend their first winter on land (Chrysemys picta marginata & C. p. bellii). These turtles are unique as they are the only reptiles, and highest vertebrate life form, known to tolerate prolonged natural freezing of extracellular body fluids during winter hibernation.[12] These advances may aid the development of organ cryopreservation technology.[4] A second area of his research is metabolic rate depression - understanding the mechanisms by which some animals can sharply reduce their metabolism and enter a state of hypometabolism or torpor that allows them to survive over the long term under difficult environmental stresses. His studies have identified molecular mechanisms that underlie metabolic arrest across phylogeny and that support phenomena including mammalian hibernation, estivation, and anoxia and ischemia tolerance. Control mechanisms include transcription factor changes that alter gene expression, and reversible phosphorylation of key metabolic enzymes by protein kinases and protein phosphatases. These studies across multiple species also hold key applications for medical science, particularly for preservation technologies that aim to extend the survival time of excised organs in cold or frozen storage.[4] Additional applications include insights into hyperglycemia in metabolic syndrome and diabetes,[13] and anoxic and ischemic damage caused by heart attack and stroke.[14] Furthermore, Storey's lab has created several web based programs freely available for data management, data plotting, and micro RNA analysis.

Website[edit]

Main Page

Personal Profile

Selected recent publications[edit]

Full list on Google Scholar

Full list on PubMed

Books[edit]

  • Storey, K.B.; Tanino, K.K., eds. (2012). Temperature Adaptation in a Changing Climate. Walllingford: CABI Publishers.

Selected Review Articles[edit]

  • Luu, B.E.; Storey, K.B. (2018). "Solving Donor Organ Shortage with Insights from Freeze Tolerance in Nature: Activating endogenous antioxidant systems with non-coding RNA to precondition donor organs". BioEssays. 40 (10): e1800092. doi:10.1002/bies.201800092. PMID 30152131.
  • Hadj-Moussa, H.; Green, S.R.; Storey, K.B. (2018). "The Living Dead: Mitochondria and Metabolic Arrest". IUBMB Life. 70 (12): 1260–1266. doi:10.1002/iub.1910. PMID 30152131.
  • Biggar, K.K.; Storey, K.B (2018). "Functional impact of microRNA regulation in models of extreme stress adaptation". K.B. 10 (2): 93–101. doi:10.1093/jmcb/mjx053. PMID 29206937.
  • Storey, K.B.; Storey, J.M. (2017). "Molecular Physiology of Freeze Tolerance in Vertebrates". Physiological Reviews. 97 (2): 623–665. doi:10.1152/physrev.00016.2016. PMID 28179395.
  • Wu, C.W.; Storey, K.B. (2016). "Life in the cold: links between mammalian hibernation and longevity". Biomolecular Concepts. 7 (1): 41–52. doi:10.1515/bmc-2015-0032. PMID 26820181.
  • Tessier, S.N.; Storey, K.B. (2016). "Lessons from mammalian hibernators: molecular insights into striated muscle plasticity and remodeling". Biomolecular Concepts. 7 (2): 69–92. doi:10.1515/bmc-2015-0031. PMID 26982616.
  • Zhang, J.; Hadj-Moussa, H.; Storey, K.B. (2016). "Current progress of high-throughput microRNA differential expression analysis and random forest gene selection for model and non-model systems: an R implementation". Journal of Integrative Bioinformatics. 13 (5): 35–46. doi:10.2390/biecoll-jib-2016-306. PMID 28187420.
  • Storey, K.B. (2016). "Comparative enzymology-new insights from studies of an "old" enzyme, lactate dehydrogenase". Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 199: 13–20. doi:10.1016/j.cbpb.2015.12.004. PMID 26688543.

Boards[edit]

  • Journal of Comparative Physiology B (since 1994)
  • PeerJ (since 2012)
  • Genomics, Proteomics and Bioinformatics (since 2014)
  • Past member: American Journal of Physiology, Molecular Physiology, Copeia, J. Experimental Zoology, Environmental Reviews, Biochemistry & Cell Biology, Cryo-Letters, Experimental Biology Online

Professional Positions[edit]

  • Canada Research Chair (Tier 1) in Molecular Physiology, Carleton University, Ottawa (2001–present)[4]
  • Professor of Biochemistry, Departments of Biology and Chemistry, Carleton University, Ottawa (1989–present)
  • Professor of Biochemistry and Biology, Carleton University, Ottawa (1985-1989)
  • Associate Professor of Biochemistry and Biology, Carleton University, Ottawa (1979-1985)
  • Assistant Professor of Zoology, Duke University, Durham, North Carolina (1974-1979)

Professional Honours[edit]

List of Honours

Recent Research Activities[edit]

List of Research Activities

References[edit]