As a member of the R&B group Intro, Greene wrote and produced most, if not all, of the group's tracks and was lead vocalist. He also wrote many songs for other artists, such as Mary J. Blige's "Reminisce" and "Love No Limit." For his work with Blige, Greene won the Songwriter of the Year award from the American Society of Composers, Authors & Publishers'. Greene also worked with Will Smith, Cam'ron and 98 Degrees.
The last time he recorded was early in 2001 singing background vocals for Tyrese on the song "For Always" on the 2000 Watts album.
In a 2001 interview with Sister 2 Sister magazine, Greene revealed that he was bisexual and that he was suffering from AIDS. He died in New York City at the age of 32 due to complications of the disease.