Keratin 10

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KRT10
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesKRT10, BCIE, BIE, CK10, EHK, K10, KPP, keratin 10
External IDsOMIM: 148080 GeneCards: KRT10
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for KRT10
Genomic location for KRT10
Band17q21.2Start40,818,117 bp[1]
End40,822,614 bp[1]
RNA expression pattern
PBB GE KRT10 210633 x at fs.png

PBB GE KRT10 213287 s at fs.png

PBB GE KRT10 207023 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000421

n/a

RefSeq (protein)

NP_000412

n/a

Location (UCSC)Chr 17: 40.82 – 40.82 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Keratin, type I cytoskeletal 10 also known as cytokeratin-10 (CK-10) or keratin-10 (K10) is a protein that in humans is encoded by the KRT10 gene.[3][4][5] Keratin 10 is a type I keratin.

Function[edit]

Keratin-10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.[5]

Interactions[edit]

Keratin 10 has been shown to interact with AKT1.[6]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186395 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Lessin SR, Huebner K, Isobe M, Croce CM, Steinert PM (Jan 1989). "Chromosomal mapping of human keratin genes: evidence of non-linkage". J Invest Dermatol. 91 (6): 572–8. doi:10.1111/1523-1747.ep12477087. PMID 2461420.
  4. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  5. ^ a b "Entrez Gene: KRT10 keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris)".
  6. ^ Paramio, J M; Segrelles C; Ruiz S; Jorcano J L (Nov 2001). "Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest". Mol. Cell. Biol. United States. 21 (21): 7449–59. doi:10.1128/MCB.21.21.7449-7459.2001. ISSN 0270-7306. PMC 99917. PMID 11585925.

Further reading[edit]