Keratin 10

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KRT10
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases KRT10, BCIE, BIE, CK10, EHK, K10, KPP, keratin 10
External IDs OMIM: 148080 GeneCards: KRT10
RNA expression pattern
PBB GE KRT10 210633 x at fs.png

PBB GE KRT10 213287 s at fs.png

PBB GE KRT10 207023 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000421

n/a

RefSeq (protein)

NP_000412

n/a

Location (UCSC) Chr 17: 40.82 – 40.82 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Keratin, type I cytoskeletal 10 also known as cytokeratin-10 (CK-10) or keratin-10 (K10) is a protein that in humans is encoded by the KRT10 gene.[2][3][4] Keratin 10 is a type I keratin.

Function[edit]

Keratin-10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.[4]

Interactions[edit]

Keratin 10 has been shown to interact with AKT1.[5]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Lessin SR, Huebner K, Isobe M, Croce CM, Steinert PM (Jan 1989). "Chromosomal mapping of human keratin genes: evidence of non-linkage". J Invest Dermatol. 91 (6): 572–8. doi:10.1111/1523-1747.ep12477087. PMID 2461420. 
  3. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177Freely accessible. PMID 16831889. 
  4. ^ a b "Entrez Gene: KRT10 keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris)". 
  5. ^ Paramio, J M; Segrelles C; Ruiz S; Jorcano J L (Nov 2001). "Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest". Mol. Cell. Biol. United States. 21 (21): 7449–59. doi:10.1128/MCB.21.21.7449-7459.2001. ISSN 0270-7306. PMC 99917Freely accessible. PMID 11585925. 

Further reading[edit]