Keratin 13

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Keratin 13, type I
Symbols KRT13 ; CK13; K13; WSN2
External IDs OMIM148065 MGI101925 HomoloGene40740 GeneCards: KRT13 Gene
Species Human Mouse
Entrez 3860 16663
Ensembl ENSG00000171401 ENSMUSG00000044041
UniProt P13646 P08730
RefSeq (mRNA) NM_002274 NM_010662
RefSeq (protein) NP_002265 NP_034792
Location (UCSC) Chr 17:
41.5 – 41.51 Mb
Chr 11:
100.12 – 100.12 Mb
PubMed search [1] [2]

Keratin 13 (or cytokeratin 13) is a protein that in humans is encoded by the KRT13 gene.[1][2]

Keratin 13 is a type I cytokeratin, it is paired with keratin 4 and found in the suprabasal layers of non-cornified stratified epithelia. Mutations in the gene encoding this protein and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus.[3]

K13 is negative in buccal epithelium.[citation needed]


  1. ^ Romano V, Raimondi E, Bosco P, Feo S, Di Pietro C, Leube RE, Troyanovsky SM, Ceratto N (October 1992). "Chromosomal mapping of human cytokeratin 13 gene (KRT13)". Genomics 14 (2): 495–7. doi:10.1016/S0888-7543(05)80250-2. PMID 1385306. 
  2. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889. 
  3. ^ Richard G, De Laurenzi V, Didona B, Bale SJ, Compton JG (December 1995). "Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus". Nat. Genet. 11 (4): 453–5. doi:10.1038/ng1295-453. PMID 7493031. 

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