Keratin 13

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KRT13
Identifiers
AliasesKRT13, CK13, K13, WSN2, keratin 13
External IDsOMIM: 148065 MGI: 101925 HomoloGene: 40740 GeneCards: KRT13
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for KRT13
Genomic location for KRT13
Band17q21.2Start41,500,981 bp[1]
End41,505,705 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_153490
NM_002274

NM_010662
NM_001313949

RefSeq (protein)

NP_002265
NP_705694

NP_001300878
NP_034792

Location (UCSC)Chr 17: 41.5 – 41.51 MbChr 11: 100.12 – 100.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Keratin 13 (or cytokeratin 13) is a protein that in humans is encoded by the KRT13 gene.[5][6]

Keratin 13 is a type I cytokeratin, it is paired with keratin 4 and found in the suprabasal layers of non-cornified stratified epithelia. Mutations in the gene encoding this protein and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171401 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044041 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Romano V, Raimondi E, Bosco P, Feo S, Di Pietro C, Leube RE, Troyanovsky SM, Ceratto N (October 1992). "Chromosomal mapping of human cytokeratin 13 gene (KRT13)". Genomics. 14 (2): 495–7. doi:10.1016/S0888-7543(05)80250-2. PMID 1385306.
  6. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  7. ^ Richard G, De Laurenzi V, Didona B, Bale SJ, Compton JG (December 1995). "Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus". Nat. Genet. 11 (4): 453–5. doi:10.1038/ng1295-453. PMID 7493031.

Further reading[edit]