Keratin 13

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KRT13
Identifiers
Aliases KRT13, CK13, K13, WSN2, keratin 13
External IDs OMIM: 148065 MGI: 101925 HomoloGene: 40740 GeneCards: 3860
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_153490
NM_002274

NM_010662
NM_001313949

RefSeq (protein)

NP_002265.2
NP_705694.2

NP_001300878.1
NP_034792.1

Location (UCSC) Chr 17: 41.5 – 41.51 Mb Chr 11: 100.12 – 100.12 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Keratin 13 (or cytokeratin 13) is a protein that in humans is encoded by the KRT13 gene.[3][4]

Keratin 13 is a type I cytokeratin, it is paired with keratin 4 and found in the suprabasal layers of non-cornified stratified epithelia. Mutations in the gene encoding this protein and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus.[5]

K13 is negative in buccal epithelium.[citation needed]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Romano V, Raimondi E, Bosco P, Feo S, Di Pietro C, Leube RE, Troyanovsky SM, Ceratto N (October 1992). "Chromosomal mapping of human cytokeratin 13 gene (KRT13)". Genomics. 14 (2): 495–7. doi:10.1016/S0888-7543(05)80250-2. PMID 1385306. 
  4. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177free to read. PMID 16831889. 
  5. ^ Richard G, De Laurenzi V, Didona B, Bale SJ, Compton JG (December 1995). "Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus". Nat. Genet. 11 (4): 453–5. doi:10.1038/ng1295-453. PMID 7493031. 

Further reading[edit]