Keratin 17

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Keratin 17, type I
Symbols KRT17 ; 39.1; CK-17; K17; PC; PC2; PCHC1
External IDs OMIM148069 MGI96691 HomoloGene363 GeneCards: KRT17 Gene
RNA expression pattern
PBB GE KRT17 205157 s at tn.png
PBB GE KRT17 212236 x at tn.png
More reference expression data
Species Human Mouse
Entrez 3872 16667
Ensembl ENSG00000128422 ENSMUSG00000035557
UniProt Q04695 Q9QWL7
RefSeq (mRNA) NM_000422 NM_010663
RefSeq (protein) NP_000413 NP_034793
Location (UCSC) Chr 17:
41.62 – 41.62 Mb
Chr 11:
100.26 – 100.26 Mb
PubMed search [1] [2]

Keratin, type I cytoskeletal 17 is a protein that in humans is encoded by the KRT17 gene.[1][2][3][4]

Keratin 17 is a type I cytokeratin. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.[4]


Keratin 17 has been shown to interact with CCDC85B.[5]


  1. ^ McLean WH, Rugg EL, Lunny DP, Morley SM, Lane EB, Swensson O, Dopping-Hepenstal PJ, Griffiths WA, Eady RA, Higgins C (Jul 1995). "Keratin 16 and keratin 17 mutations cause pachyonychia congenita". Nat Genet 9 (3): 273–8. doi:10.1038/ng0395-273. PMID 7539673. 
  2. ^ Troyanovsky SM, Leube RE, Franke WW (Jan 1993). "Characterization of the human gene encoding cytokeratin 17 and its expression pattern". Eur J Cell Biol 59 (1): 127–37. PMID 1281771. 
  3. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889. 
  4. ^ a b "Entrez Gene: KRT17 keratin 17". 
  5. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

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