Keratin 17

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Keratin 17, type I
Symbols KRT17 ; K17; PC; PC2; PCHC1
External IDs OMIM148069 MGI96691 HomoloGene363 GeneCards: KRT17 Gene
RNA expression pattern
PBB GE KRT17 205157 s at tn.png
PBB GE KRT17 212236 x at tn.png
More reference expression data
Species Human Mouse
Entrez 3872 16667
Ensembl ENSG00000128422 ENSMUSG00000035557
UniProt Q04695 Q9QWL7
RefSeq (mRNA) NM_000422 NM_010663
RefSeq (protein) NP_000413 NP_034793
Location (UCSC) Chr 17:
41.62 – 41.62 Mb
Chr 11:
100.26 – 100.26 Mb
PubMed search [1] [2]

Keratin, type I cytoskeletal 17 is a protein that in humans is encoded by the KRT17 gene.[1][2][3][4]

Keratin 17 is a type I cytokeratin. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.[4]


Keratin 17 has been shown to interact with CCDC85B.[5]


  1. ^ McLean WH, Rugg EL, Lunny DP, Morley SM, Lane EB, Swensson O et al. (Jul 1995). "Keratin 16 and keratin 17 mutations cause pachyonychia congenita". Nat Genet 9 (3): 273–8. doi:10.1038/ng0395-273. PMID 7539673. 
  2. ^ Troyanovsky SM, Leube RE, Franke WW (Jan 1993). "Characterization of the human gene encoding cytokeratin 17 and its expression pattern". Eur J Cell Biol 59 (1): 127–37. PMID 1281771. 
  3. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM et al. (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889. 
  4. ^ a b "Entrez Gene: KRT17 keratin 17". 
  5. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

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