Keratin 18

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AliasesKRT18, CK-18, CYK18, K18, keratin 18
External IDsOMIM: 148070 MGI: 96692 HomoloGene: 55448 GeneCards: KRT18
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for KRT18
Genomic location for KRT18
Band12q13.13Start52,948,871 bp[1]
End52,952,906 bp[1]
RNA expression pattern
PBB GE KRT18 201596 x at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 12: 52.95 – 52.95 MbChr 15: 102.03 – 102.03 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.[5]

Keratin 18 is often used together with keratin 8 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.[6]


Keratin 18 has been shown to interact with Collagen, type XVII, alpha 1,[7] DNAJB6,[8] Pinin[9] and TRADD.[10]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111057 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023043 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: KRT18 keratin 18".
  6. ^ W. Jeffrey Allard; Jeri Matera; M. Craig Miller; et al. (October 2004). "Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients With Nonmalignant Diseases". Clin. Cancer Research. 10 (20): 6897–6904. doi:10.1158/1078-0432.CCR-04-0378. PMID 15501967.
  7. ^ Aho, S; Uitto J (March 1999). "180-kD bullous pemphigoid antigen/type XVII collagen: tissue-specific expression and molecular interactions with keratin 18". J. Cell. Biochem. 72 (3): 356–67. doi:10.1002/(SICI)1097-4644(19990301)72:3<356::AID-JCB5>3.0.CO;2-M. ISSN 0730-2312. PMID 10022517.
  8. ^ Izawa, I; Nishizawa M; Ohtakara K; Ohtsuka K; Inada H; Inagaki M (November 2000). "Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein". J. Biol. Chem. 275 (44): 34521–7. doi:10.1074/jbc.M003492200. ISSN 0021-9258. PMID 10954706.
  9. ^ Shi, J; Sugrue S P (May 2000). "Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus". J. Biol. Chem. 275 (20): 14910–5. doi:10.1074/jbc.275.20.14910. ISSN 0021-9258. PMID 10809736.
  10. ^ Inada, H; Izawa I; Nishizawa M; Fujita E; Kiyono T; Takahashi T; Momoi T; Inagaki M (October 2001). "Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD". J. Cell Biol. 155 (3): 415–26. doi:10.1083/jcb.200103078. ISSN 0021-9525. PMC 2150850. PMID 11684708.

Further reading[edit]