Keratin 34

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Keratin 34, type I
Symbols KRT34 ; HA4; Ha-4; KRTHA4; hHa4
External IDs OMIM602763 MGI1309994 HomoloGene31083 GeneCards: KRT34 Gene
RNA expression pattern
PBB GE KRT34 206969 at tn.png
PBB GE KRT31 208483 x at tn.png
More reference expression data
Species Human Mouse
Entrez 3885 16672
Ensembl ENSG00000131737 ENSMUSG00000043485
UniProt O76011 Q9D646
RefSeq (mRNA) NM_021013 NM_027563
RefSeq (protein) NP_066293 NP_081839
Location (UCSC) Chr 17:
41.38 – 41.38 Mb
Chr 11:
100.04 – 100.04 Mb
PubMed search [1] [2]

Keratin, type I cuticular Ha4 is a protein that in humans is encoded by the KRT34 gene.[1][2][3][4]

The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription.[4]

See also[edit]


  1. ^ Heid HW, Werner E, Franke WW (Feb 1987). "The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins". Differentiation 32 (2): 101–19. doi:10.1111/j.1432-0436.1986.tb00562.x. PMID 2431943. 
  2. ^ Rogers MA, Winter H, Wolf C, Heck M, Schweizer J (Nov 1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J Biol Chem 273 (41): 26683–91. doi:10.1074/jbc.273.41.26683. PMID 9756910. 
  3. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889. 
  4. ^ a b "Entrez Gene: KRT34 keratin 34". 

Further reading[edit]