The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription.
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^Rogers MA, Winter H, Wolf C, Heck M, Schweizer J (Nov 1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J Biol Chem273 (41): 26683–91. doi:10.1074/jbc.273.41.26683. PMID9756910.
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Langbein L, Rogers MA, Winter H et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle.". J. Biol. Chem.274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID10391933.