Keratin 4

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Keratin 4, type II
Symbols KRT4 ; CK-4; CK4; CYK4; K4; WSN1
External IDs OMIM123940 MGI96701 HomoloGene20523 GeneCards: KRT4 Gene
Species Human Mouse
Entrez 3851 16682
Ensembl ENSG00000170477 ENSMUSG00000059668
UniProt P19013 P07744
RefSeq (mRNA) NM_002272 NM_008475
RefSeq (protein) NP_002263 NP_032501
Location (UCSC) Chr 12:
52.81 – 52.81 Mb
Chr 15:
101.92 – 101.92 Mb
PubMed search [1] [2]

Keratin, type I cytoskeletal 4 also known as cytokeratin-4 (CK-4) or keratin-4 (K4) is a protein that in humans is encoded by the KRT4 gene.[1][2]

Keratin 4 is a type II cytokeratins. It is specifically found in differentiated layers of the mucosal and esophageal epithelia together with keratin 13. Mutations in the genes encoding this protein have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia.[3]


  1. ^ Barletta C, Batticane N, Ragusa RM, Leube R, Peschle C, Romano V (1990). "Subchromosomal localization of two human cytokeratin genes (KRT4 and KRT15) by in situ hybridization". Cytogenet. Cell Genet. 54 (3–4): 148–50. doi:10.1159/000132979. PMID 1702379. 
  2. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889. 
  3. ^ Chao SC, Tsai YM, Yang MH, Lee JY (June 2003). "A novel mutation in the keratin 4 gene causing white sponge naevus". Br. J. Dermatol. 148 (6): 1125–8. doi:10.1046/j.1365-2133.2003.05337.x. PMID 12828738. 

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