Keratinocyte growth factor

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The keratinocyte growth factor (KGF), also known as FGF7, is a growth factor present in the epithelialization-phase of wound healing. In this phase, keratinocytes are covering the wound, forming the epithelium.

KGF is a small signaling molecule that binds to fibroblast growth factor receptor 2b (FGFR2b).[1] For signalling to occur, a dimer is required between two FGF:FGFR complexes that is linked together by a molecule of heparin.

There are 23 known FGFs, and 4 FGF receptors. FGF:FGFR binding is complex and regulated by a variety of mechanisms in a tissue specific manner.

FGF10 is also known as "keratinocyte growth factor 2".[2]

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References[edit]

  1. ^ Rotolo S, Ceccarelli S, Romano F, Frati L, Marchese C, Angeloni A (2008). Maas S, ed. "Silencing of Keratinocyte Growth Factor Receptor Restores 5-Fluorouracil and Tamoxifen Efficacy on Responsive Cancer Cells". PLoS ONE. 3 (6): e2528. doi:10.1371/journal.pone.0002528. PMC 2424182. PMID 18575591. open access
  2. ^ "iHOP - Information Hyperlinked over Proteins [ FGF10 ]".

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