Keratinocyte transglutaminase

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Transglutaminase 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TGM1 ; ARCI1; ICR2; KTG; LI; LI1; TGASE; TGK
External IDs OMIM190195 MGI98730 HomoloGene306 ChEMBL: 2810 GeneCards: TGM1 Gene
EC number 2.3.2.13
RNA expression pattern
PBB GE TGM1 206008 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7051 21816
Ensembl ENSG00000092295 ENSMUSG00000022218
UniProt P22735 Q9JLF6
RefSeq (mRNA) NM_000359 NM_001161714
RefSeq (protein) NP_000350 NP_001155186
Location (UCSC) Chr 14:
24.25 – 24.26 Mb
Chr 14:
55.7 – 55.71 Mb
PubMed search [1] [2]

Protein-glutamine gamma-glutamyltransferase K is an enzyme that in humans is encoded by the TGM1 gene.[1][2]

Keratinocyte transglutaminase is a transglutaminase enzyme.

Pathology[edit]

A deficiency is associated with ichthyosis lamellaris.[3] Epidermal transglutaminase is the autoantigen, in humans, of dermatitis herpetiformis.

See also[edit]

References[edit]

  1. ^ Grenard P, Bates MK, Aeschlimann D (Aug 2001). "Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z". J Biol Chem 276 (35): 33066–78. doi:10.1074/jbc.M102553200. PMID 11390390. 
  2. ^ "Entrez Gene: TGM1 transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)". 
  3. ^ Hennies HC, Küster W, Wiebe V, Krebsová A, Reis A (1998). "Genotype/phenotype correlation in autosomal recessive lamellar ichthyosis". Am. J. Hum. Genet. 62 (5): 1052–61. doi:10.1086/301818. PMC 1377076. PMID 9545389. 

Further reading[edit]

  • Phillips MA, Stewart BE, Rice RH (1992). "Genomic structure of keratinocyte transglutaminase. Recruitment of new exon for modified function.". J. Biol. Chem. 267 (4): 2282–6. PMID 1346394. 
  • Kim IG, McBride OW, Wang M et al. (1992). "Structure and organization of the human transglutaminase 1 gene.". J. Biol. Chem. 267 (11): 7710–7. PMID 1348508. 
  • Polakowska RR, Eickbush T, Falciano V et al. (1992). "Organization and evolution of the human epidermal keratinocyte transglutaminase I gene.". Proc. Natl. Acad. Sci. U.S.A. 89 (10): 4476–80. doi:10.1073/pnas.89.10.4476. PMC 49105. PMID 1350092. 
  • Schroeder WT, Thacher SM, Stewart-Galetka S et al. (1992). "Type I keratinocyte transglutaminase: expression in human skin and psoriasis.". J. Invest. Dermatol. 99 (1): 27–34. doi:10.1111/1523-1747.ep12611394. PMID 1351505. 
  • Yamanishi K, Inazawa J, Liew FM et al. (1992). "Structure of the gene for human transglutaminase 1.". J. Biol. Chem. 267 (25): 17858–63. PMID 1381356. 
  • Kim HC, Idler WW, Kim IG et al. (1991). "The complete amino acid sequence of the human transglutaminase K enzyme deduced from the nucleic acid sequences of cDNA clones.". J. Biol. Chem. 266 (1): 536–9. PMID 1670769. 
  • Yamanishi K, Liew FM, Konishi K et al. (1991). "Molecular cloning of human epidermal transglutaminase cDNA from keratinocytes in culture.". Biochem. Biophys. Res. Commun. 175 (3): 906–13. doi:10.1016/0006-291X(91)91651-R. PMID 1673840. 
  • Polakowska R, Herting E, Goldsmith LA (1991). "Isolation of cDNA for human epidermal type I transglutaminase.". J. Invest. Dermatol. 96 (2): 285–8. doi:10.1111/1523-1747.ep12464554. PMID 1704039. 
  • Phillips MA, Stewart BE, Qin Q et al. (1991). "Primary structure of keratinocyte transglutaminase.". Proc. Natl. Acad. Sci. U.S.A. 87 (23): 9333–7. doi:10.1073/pnas.87.23.9333. PMC 55159. PMID 1979171. 
  • Candi E, Melino G, Mei G et al. (1995). "Biochemical, structural, and transglutaminase substrate properties of human loricrin, the major epidermal cornified cell envelope protein.". J. Biol. Chem. 270 (44): 26382–90. doi:10.1074/jbc.270.44.26382. PMID 7592852. 
  • Mariniello L, Esposito C, Di Pierro P et al. (1993). "Human-immunodeficiency-virus transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro.". Eur. J. Biochem. 215 (1): 99–104. doi:10.1111/j.1432-1033.1993.tb18011.x. PMID 7688299. 
  • Russell LJ, DiGiovanna JJ, Rogers GR et al. (1995). "Mutations in the gene for transglutaminase 1 in autosomal recessive lamellar ichthyosis.". Nat. Genet. 9 (3): 279–83. doi:10.1038/ng0395-279. PMID 7773290. 
  • Huber M, Rettler I, Bernasconi K et al. (1995). "Mutations of keratinocyte transglutaminase in lamellar ichthyosis.". Science 267 (5197): 525–8. doi:10.1126/science.7824952. PMID 7824952. 
  • Amendola A, Lombardi G, Oliverio S et al. (1994). "HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A.". FEBS Lett. 339 (3): 258–64. doi:10.1016/0014-5793(94)80427-3. PMID 7906657. 
  • Kim SY, Kim IG, Chung SI, Steinert PM (1994). "The structure of the transglutaminase 1 enzyme. Deletion cloning reveals domains that regulate its specific activity and substrate specificity.". J. Biol. Chem. 269 (45): 27979–86. PMID 7961731. 
  • Steinert PM, Kim SY, Chung SI, Marekov LN (1996). "The transglutaminase 1 enzyme is variably acylated by myristate and palmitate during differentiation in epidermal keratinocytes.". J. Biol. Chem. 271 (42): 26242–50. doi:10.1074/jbc.271.39.24105. PMID 8824274. 
  • Laiho E, Ignatius J, Mikkola H et al. (1997). "Transglutaminase 1 mutations in autosomal recessive congenital ichthyosis: private and recurrent mutations in an isolated population.". Am. J. Hum. Genet. 61 (3): 529–38. doi:10.1086/515498. PMC 1715945. PMID 9326318. 
  • Tarcsa E, Marekov LN, Andreoli J et al. (1997). "The fate of trichohyalin. Sequential post-translational modifications by peptidyl-arginine deiminase and transglutaminases.". J. Biol. Chem. 272 (44): 27893–901. doi:10.1074/jbc.272.44.27893. PMID 9346937. 
  • Petit E, Huber M, Rochat A et al. (1998). "Three novel point mutations in the keratinocyte transglutaminase (TGK) gene in lamellar ichthyosis: significance for mutant transcript level, TGK immunodetection and activity.". Eur. J. Hum. Genet. 5 (4): 218–28. PMID 9359043. 
  • Iwasaki W, Nagata K, Hatanaka H et al. (1998). "Solution structure of midkine, a new heparin-binding growth factor.". EMBO J. 16 (23): 6936–46. doi:10.1093/emboj/16.23.6936. PMC 1170297. PMID 9384573. 

External links[edit]