Keratocan

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KERA
Identifiers
Aliases KERA, CNA2, KTN, SLRR2B, keratocan
External IDs MGI: 1202398 HomoloGene: 5106 GeneCards: 11081
RNA expression pattern
PBB GE KERA 220504 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007035

NM_008438

RefSeq (protein)

NP_008966.1

NP_032464.1

Location (UCSC) Chr 12: 91.05 – 91.06 Mb Chr 10: 97.61 – 97.61 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Keratocan (KTN) also known as keratan sulfate proteoglycan keratocan, is a protein that in humans is encoded by the KERA gene.[1][2][3]

Keratan sulfate proteoglycans (KSPGs) are members of the small leucine-rich proteoglycan (SLRP) family. KSPGs, particularly keratocan, lumican and mimecan, are important to the transparency of the cornea.[3]

Mutations of the gene cause cornea plana 2.

References[edit]

  1. ^ Tasheva ES, Funderburgh JL, Funderburgh ML, Corpuz LM, Conrad GW (Jan 2000). "Structure and sequence of the gene encoding human keratocan". DNA Seq 10 (1): 67–74. doi:10.3109/10425179909033939. PMID 10565548. 
  2. ^ Pellegata NS, Dieguez-Lucena JL, Joensuu T, Lau S, Montgomery KT, Krahe R, Kivela T, Kucherlapati R, Forsius H, de la Chapelle A (Jun 2000). "Mutations in KERA, encoding keratocan, cause cornea plana". Nat Genet 25 (1): 91–5. doi:10.1038/75664. PMID 10802664. 
  3. ^ a b "Entrez Gene: KERA keratocan". 

Further reading[edit]