In addition to hosting SportsCenter, he also hosts Baseball Tonight, College Football Live and Outside the Lines on ESPN and is a fill-in anchor on NFL Live and Cold Pizza. He is the first anchor of Indian-American descent to be on a national sports network in American television history. Negandhi joined ESPN in September 2006 and made his debut on ESPNews in October 2006.
Negandhi was born in Phoenixville, Pennsylvania. Negandhi graduated from Phoenixville Area High School in Phoenixville. He received a degree in Communications from Temple University in 1997. While at Temple, he was a reporter on the Philadelphia Inquirer High School Sports Show on Fox. He also worked as a stringer for USA Today covering 6 local colleges for the Gannett News Service. He was also a member of Temple's student run newscast, Temple Update, under the direction of Rick Beardsley.  He served as sports editor at the Temple News - the school's newspaper, for two years. Negandhi was the voice of the Temple Women's basketball team on WRTI 90.1 FM in Philadelphia for three years.
Negandhi joined WWSB-TV in Sarasota, Florida in 1999 and served as a sports anchor/reporter for three years. After a year away from TV, he returned to Sarasota and became sports director at WWSB-TV from 2004-06. While working in Florida, he won three Associated Press awards including "Best Sportscast" in 2004 and 2005 and "Best Breaking Sports News" in 2005.