Khamsa (Arabic, lit. "five") may refer to:
- Hamsa, a popular amulet in the Middle East and North Africa, also romanized as khamsa
- Al Khamsa, a bloodline for Arabian horses that traces back to five mares
- Al Khamsa (organization), a nonprofit organization in the United States that supports the breeding of Al Khamsa bloodline horses
- Khamseh, a tribal people of Iran
- Khamsa (film), a 2008 film
- Khamsa of Nizami (British Library, Or. 12208), the manuscript of the five poems of Nezami Ganjavi
- Principality of Khachen, also known as Khamsa, the five Armenian Melikdoms of Khachen during the Middle Ages
- Hamsa (disambiguation)
- Khansa (disambiguation)
|This disambiguation page lists articles associated with the title Khamsa.
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