Killbuck Creek is a tributary of the Walhonding River,  81.7 mi (131.5 km) long, in north-central Ohio in the United States. Via the Walhonding, Muskingum and Ohio Rivers, it is part of the watershed of the Mississippi River. It drains an area of 613 mi² (1588 km²).
Killbuck Creek rises in northern Wayne County and initially flows in a counter-clockwise loop northward into southern Medina County and past the town of Burbank before turning to a southward course through Wayne, Holmes and Coshocton Counties to its mouth at the Walhonding River, 5 mi (8 km) west of the city of Coshocton. Along its course it flows to the west of the city of Wooster and passes the towns of Holmesville, Millersburg and Killbuck.
Killbuck Creek and the town of Killbuck are named for the Shawnee war chief Bemino (fl. 1710s–1780s) — known as John Killbuck, Sr, to the whites. According to the Geographic Names Information System, the stream has been known and spelled variously over the years:
- Kilbuck Creek
- Killbuck Run
- Killbucks Creek
- Kilbuck River
- Kill-Buck River
The United States Board on Geographic Names settled on "Killbuck Creek" as the stream's name in 1963.
- Columbia Gazetteer of North America entry
- Ohio Department of Natural Resources. A Guide to Ohio Streams. Archived 2005-09-04 at the Wayback Machine. Chapter 10: Major Ohio Watersheds (pdf)
- *DeLorme (1991). Ohio Atlas & Gazetteer. Yarmouth, Maine: DeLorme. ISBN 0-89933-233-1
- Hunt, William Ellis (1876). Historical Collections of Coshocton County, Ohio: A Complete Panorama of the County, from the Time of the Earliest Known Occupants of the Territory Unto the Present Time, 1764-1876. R. Clarke & Company. p. 14.
- U.S. Geological Survey Geographic Names Information System: Killbuck Creek