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Killer Joe may refer to:
- "Killer Joe", a jazz standard composed by Benny Golson and featured on the 1960 album Meet the Jazztet
- Killer Joe (Jimmy Osmond album), 1972
- Killer Joe (George Kawaguchi & Art Blakey album), 1981
- Killer Joe (play), a 1993 play by Tracy Letts
- Killer Joe (film), a 2011 film directed by William Friedkin
- Killer Joe Piro (1921–1989), a dance instructor
- Killer Joe, a band formed by Australian jazz vocalist Joe Lane
- "Killer Joe", a 1963 song performed by the Rocky Fellers and the Rivieras
| disambiguation page lists articles associated with the title Killer Joe.
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