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potassium inwardly-rectifying channel, subfamily J, member 18
Symbol KCNJ18
Entrez 100134444
HUGO 39080
OMIM 613236
RefSeq NM_001194958
UniProt B7U540
Other data
Locus Chr. 17 p11.2

The Kir2.6 also known as inward rectifier potassium channel 18 is a protein that in humans is encoded by the KCNJ18 gene.[1] Kir2.6 is an inward-rectifier potassium ion channel.


Inwardly rectifying potassium channels, such as Kir2.6, maintain resting membrane potential in excitable cells and aid in repolarization of cells following depolarization. Kir2.6 is primarily expressed in skeletal muscle and is transcriptionally regulated by thyroid hormone.[1]

Clinical signifiance[edit]

Mutations in this gene have been linked to thyrotoxic periodic paralysis.[1]


This article incorporates text from the United States National Library of Medicine, which is in the public domain.