In this park are found 11 species of mammals of which 10 are endemic. Among them figures also the Madame Berthe's mouse lemur, the smallest primate in the world, that is only known from this park. Also the fossa, Madagascar's largest predator, and the lemurs only predator (apart from man). Other mammals endemic to the Menabe region include the giant jumping rat (Hypogeomys antimena) and the narrow-striped mongoose (Mungotictis decemlineata).
Furthermore there are 47 species of birds (33 endemic) and 23 species of reptiles.