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Kirs may refer to:
- Rudolf Kirs (1915–1963), Czech cellist
- Urmas Kirs (b. 1966), Estonian footballer and manager
- Vallo Kirs (b. 1987), Estonian actor
- Kirs, inwardly-rectifying potassium channels
- KIRS (FM), a radio station (107.7 FM) licensed to serve Stockton, Missouri, United States