He was the son of a wealthy farming family from Tōno, Iwate. He attended Shiritsu Tetsugakukan (now Toyo University) and then graduated with a degree in literature from Waseda University in 1905. In 1908, he became acquainted with Kunio Yanagita, and Sasaki began to collaborate with Yanagita on collecting the oral traditions and tales of Iwate Prefecture. In his later years, he became friends with the poet Kenji Miyazawa with whom he shared his discoveries. Sasaki suffered from respiratory problems and died at the age of 47.
Professionally, Sasaki published a number of books of collected folktales and customs.
- Sadler, A. W. (1987) "The Spirit-Captives of Japan's North Country: Nineteenth Century Narratives of the Kamikakushi" Asian Folklore Studies 46: pp. 217-226.
- Dorson, Richard M. (1975) "National Characteristics of Japanese Folktales" Journal of the Folklore Institute 12(2/3): pp. 241-256, pages 242 and 248
- Dorson, Richard M. (1975) "Foreword" in Kunio, Yanagita (1975) The legends of Tono (translated with an introduction by Ronald A. Morse) Japan Foundation, Tokyo, OCLC 262297619
- Yamada, Norio (1977) 柳田国男の光と影 : 佐々木喜善物語 (Yanagita Kunio no hikari to kage, Kunio Yanagida's light and shadow: A Biography of Kizen Sasaki) 農山漁村文化協会 (Rural Cultural Association); electronic location Hathi Trust Digital Library (search only)