Knowledge translation (KT) is the umbrella term for all of the activities involved in moving research from the laboratory, the research journal, and the academic conference into the hands of people and organizations who can put it to practical use. The term is most often used relative to the health professions, including medicine, nursing, pharmaceuticals, rehabilitation, and public health.
Depending on the type of research being translated, the "practical user" might be a medical doctor, a nurse, a teacher, a school administrator, an occupational or physical therapist, a legislator, an epidemiologist, a community health worker, or a parent.
The most widely used definition of knowledge translation was published in 2000 by the Canadian Institutes of Health Research (CIHR): "Knowledge translation (KT) is defined as a dynamic and iterative process that includes synthesis, dissemination, exchange and ethically-sound application of knowledge to improve the health of Canadians, provide more effective health services and products and strengthen the health care system."
Using the CIHR definition as a basis, the National Center for the Dissemination of Disability Research (NCDDR) published this definition of KT in 2005: "The collaborative and systematic review, assessment, identification, aggregation, and practical application of high-quality disability and rehabilitation research by key stakeholders (i.e., consumers, researchers, practitioners, and policymakers) for the purpose of improving the lives of individuals with disabilities."
In 2006, Graham, et al., acknowledged the proliferation of related terms for the activity of knowledge translation, documenting 29 different terms used by 33 different health research funding agencies in their publications, including knowledge transfer, knowledge mobilization, knowledge exchange, implementation, and translational research.
In 2007, NCDDR re-published an overview written by Pimjai Sudsawad, then with the University of Wisconsin-Madison, now with the U.S. Department of Education, entitled: "Knowledge Translation: Introduction to Models, Strategies, and Measures". The overview correlates a variety of KT models which have been in development since at least 1976, including the Stetler Model of Research Utilization, the Coordinated Implementation Model, the Promoting Action on Research Implementation in Health Services (PARIHS) framework, the Ottawa Model of Research Utilization (OMRU), and the Knowledge to Action (KTA) process framework.
The activity of knowledge translation is observable as far back as agricultural extension services established by the Smith-Lever Act of 1914. The Smith-Lever Act formalized the relationship between United States land-grant universities and the United States Department of Agriculture (USDA) for the performance of agricultural extension. Agricultural extension agents based at the land-grant universities disseminated information to farmers and ranchers on seed development, land management and animal husbandry.
In their Technical Brief #10 2005, NCDDR points out: "KT is a relatively new term that is used to describe a relatively old problem - the underutilization of evidence-based research in systems of care. Underutilization of evidence-based research is often described as a gap between 'what is known' and 'what is currently done' in practice settings."
While evaluations of research utilization in the health fields have been going on since at least the mid-1960s, institutional interest in this long-standing issue has accelerated in the last 25 years. In 1989, the U.S. Department of Health and Human Services established the Agency for Healthcare Research and Quality. In 1997, the Canadian government endowed the Canadian Health Services Research Foundation (CHSRF) - now called the Canadian Foundation for Healthcare Improvement, or CFHI. In 2000, the Canadian government consolidated several existing agencies into the Canadian Institutes for Health Research. In 2006, the U.S. National Institutes of Health created the Clinical and Translational Science Awards, currently funding about 60 academic medical institutions across the country. The role of health research funders is increasingly playing a role in how evidence is being moved to practice, reducing the time between research and implementation.
More recently, the challenges of filtering information for knowledge translation is being increasingly addressed with Moloney, Taylor & Ralph proposing a "spillway model" to better control information flow and improve the implementation of research in healthcare. 
- Government of Canada, Canadian Institutes of Health Research, Knowledge Translation. "About Knowledge Translation - CIHR". Cihr-irsc.gc.ca. Retrieved 2012-10-31.
- National Center for the Dissemination of Disability Research. "NCDDR Knowledge Translation". Ncddr.org. Retrieved 2012-10-31.
- Graham, et al. (2006). The Journal of Continuing Education in the Health Professions, Volume 26, pp. 13–24.
- Sudsawad, P. (2007). Knowledge translation: Introduction to models, strategies, and measures. Austin, TX: Southwest Educational Development Laboratory, National Center for the Dissemination of Disability Research.
- Research Into Action - A Knowledge Translation Initiative (2005). "History of Knowledge Translation". Ktexchange.org. Retrieved 2012-10-31.
- National Center for the Dissemination of Disability Research. "Focus10Final.indd" (PDF). Retrieved 2012-10-31.
- Donabedian A. Evaluating the quality of medical care. Milbank Mem Fund Q Health Soc 1966; 44:166–206.
- "History", Canadian Foundation for Healthcare Improvement. On line.
- Holmes, B, Schellenberg, M, Schell, K, Scarrow, G. How funding agencies can support research use in healthcare: an online province-wide survey to determine knowledge translation training needs. Implementation Science. 2014. Vol 9.
- D. Cameron, J.N. Lavis, G.E. Guindon, T. Akhtar, F. Becerra-Posada, G.D. Ndossi, B. Buopha, Research to Policy & Practice Study Team [S.J. Hoffman]. 2010. "Bridging the Gaps among Research, Policy and Practice in Ten Low- and Middle-Income Countries: Development and Testing of a Questionnaire for Researchers," Health Research Policy and Systems 8(4): 1-8. doi:10.1186/1478-4505-8-4.
- G.E. Guindon, J.N. Lavis, B. Buopha, G. Shi, M.F. Sidibe, B. Turdaliyeva, Research to Policy & Practice Study Team [S.J. Hoffman]. 2010. "Bridging the Gaps among Research, Policy and Practice in Ten Low- and Middle-Income Countries: Development and Test of Questionnaire for Health-Care Providers," Health Research Policy and Systems 8(3): 1-9. doi:10.1186/1478-4505-8-3.