Knuckle pads

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Knuckle pads
Classification and external resources
Specialty rheumatology
ICD-10 M72.1
ICD-9-CM 728.79
OMIM 149100
DiseasesDB 30724
eMedicine article/1074379

Knuckle pads (also known as "Heloderma", meaning similar to the skin of the Gila monster lizard for which it is named) are circumscribed, keratotic, fibrous growths over the dorsa of the interphalangeal joints. [1] They are described as well-defined, round, plaque-like, fibrous thickening that may develop at any age, and grow to be 10 to 15mm in diameter in the course of a few weeks or months, then go away over time.[2]

Knuckle pads are sometimes associated with Dupuytren's contracture and camptodactyly,[2]:595 and histologically, the lesions are fibromas.[2]:595 Knuckle pads are generally non-responsive to treatment, including corticosteroids, and tend to recur after surgery; however, there has been some effectiveness with intralesional fluorouracil.[3]


  1. ^ Mackey, SL; Cobb, MW (1994). "Knuckle pads.". Cutis. 54 (3): 159–160. PMID 7813233. 
  2. ^ a b c James, WD; Berger, TG; Elston, DM (2005). Andrews' Diseases of the Skin: Clinical Dermatology (11th ed.). Saunders. p. 595. ISBN 0-7216-2921-0. 
  3. ^ Weiss, E; Amini, S (2007). "A Novel Treatment for Knuckle Pads With Intralesional Fluorouracil". Arch Dermatol. 143 (11): 1447–1462. doi:10.1001/archderm.143.11.1458. 

External Sources[edit]

  • Guberman D; et al. (1996). ""Knuckle pads-a forgotten skin condition " report of a case and review of the literature". Cutis. 57: 241. 
  • Ly Y; et al. (2003). "A novel mutation of keratin 9 in epidermolytic palmoplantar keratoderma combined with knuckle pads". Am J Med Genet. 120A: 345. 
  • Peterson CM; et al. (2000). "Knuckle pads: does knuckle cracking play an etiologic role?". Pediatr Dermatol. 17: 450. doi:10.1046/j.1525-1470.2000.01819.x. 

See also[edit]