After Constanze Krehl received her diploma from German secondary school in 1975 in Leipzig, she studied at the Technische Universität Dresden (Technical University Dresden) and graduated in computer science in 1980. In 1998 she was awarded the Federal Cross of Merit.
Since 2004 Constanze Angela Krehl has been a member of the Committee on Regional Development, furthermore she is member of the Delegation for relations with the countries of Central America and the Delegation to the Euro-Latin American Parliamentary Assembly. Until 2004 she was a Member of the Committee on Budgets and is still a substitute member. From 1994 until 1997 Krehl was chairwoman of the Delegation for relations with Russia and chairwoman of the Delegation to EU-Russia Parliamentary Cooperation Committee from 1997-1999 and 1999-2002.