It was launched at 17:10 UTC on 6 June 1982, using a Kosmos-3M carrier rocket, flying from Site 132/2 at the Plesetsk Cosmodrome in Northwest Russia. This was the final launch of a satellite as part of the Dnipropetrovsk Sputnik programme. The first DS launch, DS-1 No.1, occurred in 1961, and the first successful launch was Kosmos 1 in 1962.
Kosmos 1375 was placed into a low Earth orbit with a perigee of 986 kilometres (613 mi), an apogee of 1,003 kilometres (623 mi), 65.8 degrees of inclination, and an orbital period of 105 minutes. On 18 June 1982, it was successfully intercepted and destroyed by Kosmos 1379 in the final Soviet anti-satellite weapons test to be conducted. As of 2009, debris is still in orbit.
Kosmos 1375 was the last of ten Lira satellites to be launched, of which all but the first were successful. Lira was derived from the earlier DS-P1-M satellite, which it replaced.
Payloads are separated by bullets ( · ), launches by pipes ( | ). Manned flights are indicated in bold text. Uncatalogued launch failures are listed in italics. Payloads deployed from other spacecraft are denoted in (brackets).