Born in Constantinople (now Istanbul) in 1897, he started his football career as a young player in Turkey, playing for the Propontida Tataoulon. Later he joined Fenerbahçe S.K. where he won 3 amateur champioships.In 1918 alongside other Greeks from Pera he founded Pera Club, which he joined as a player. With Pera Club he won a Turkish Championship in 1922. After the Greco-Turkish War in 1922, Pera Club did a tour in Europe with Greece being one of their stops. Negrepontis decided to stay in France where he played for a number of french football teams. Negrepontis eventually settled in Greece to play for AEK Athens F.C. in 1926, where he became a crowd favourite and the team captain. In 1932 he retired as a footballer.