Born in Chiba, Japan, he first came to public attention as an editor of Puff magazine, his first job after completing high school. Fujishima originally intended to be a draftsman, but took the editorial role after failing to get a drafting apprenticeship. He later became assistant to manga artist Tatsuya Egawa in the production of the Making Be Free! manga, and in 1986 began his first original manga series You're Under Arrest. His second manga series Oh My Goddess!, also translated as Ah! My Goddess, is extremely popular and has made Fujishima a household name in Japan. In addition, he is also well known as the character designer for several games in the Tales RPG video game series and Sakura Wars.
He is known for his love of automobiles and motorcycles, and several of his series and their characters reflect this, such as in éX-Driver and Oh My Goddess!.