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Krüppel is a gap gene originally described in Drosophila melanogaster, which encodes a zinc finger transcription factor with four tandemly repeated zinc finger domains.[1]

Krüppel means, literally, "cripple" in German, named for the crippled appearance of mutant larva. Krüppel regulates the expression of several other gap genes.[2]

See also Kruppel-like factors which have been recently[when?] investigated in the heart but are well characterized for their role in carcinogenesis.


  1. ^ Online Mendelian Inheritance in Man (OMIM) 165220
  2. ^ Interactive Fly, Drosophila

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