Krukenberg's spindle

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Krukenberg's Spindle
Cornea showing Krukenberg's Spindle.jpg
Slit lamp photograph showing Krukenberg's Spindle as pigment cell deposits on the cornea
Classification and external resources
ICD-9-CM 364.53
OMIM 600510
DiseasesDB 31301

Krukenberg's spindle is the name given to the pattern formed on the inner surface of the cornea by pigmented iris cells which are deposited as a result of the currents of the aqueous humor. The sign was described in 1899 by Friedrich Ernst Krukenberg (1871-1946), who was a German pathologist specialising in Ophthalmology.[1]

Differential diagnosis[edit]


  • Painful red eye with photophobia associated with inflammation

Vortex keratopathy[edit]

Corneal guttata[edit]

  • Non-transparent collagen deposits appearing following loss of corneal endothelial cells[3]

See also[edit]


  1. ^ Krukenberg F. (1899) Beiderseitige angeborene Melanose der Hornhaut. Klin Mbl Augenheilkd 37:254-258.
  2. ^ Chew, E; Ghosh, M; McCulloch, C (June 1982). "Amiodarone-induced cornea verticillata.". Canadian journal of ophthalmology. Journal canadien d'ophtalmologie. 17 (3): 96–9. PMID 7116220. 
  3. ^ Akimune C, Watanabe H, Maeda N, et al. (January 2000). "Corneal guttata associated with the corneal dystrophy resulting from a betaig-h3 R124H mutation". 84 (1): 67–71. PMC 1723238Freely accessible. PMID 10611102.