Originally named De Cuylen, Kuils River was a post of the Dutch East India Company. It developed into a village during the 18th century and attained municipal status in 1950. The town takes its name from the nearby river, in which there are many pools, or kuile.
Kuils River is a level two administrative region, and is close to Cape Town's wine routes. It is located near the intersection of the M12 and the R102.
Kuils River is home to the Alta du Toit School for mentally handicapped children. and is the birthplace of Herman Charles Bosman (3 February 1905); journalist, poet and author. He is regarded as one of South Africa's greatest writers (in English).