Kukoamines

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Kukoamine A[1]
2D Structure
Kukoamines 3D structure
Names
Preferred IUPAC name
3-(3,4-Dihydroxyphenyl)-N-[3-[4-[3-[3-(3,4-dihydroxyphenyl)propanoylamino]propylamino]butylamino]propyl]propanamide
Other names
Kukoamine a
N(1),N(12)-bis(dihydrocaffeoyl)spermine
CHEMBL79129
75288-96-9
CHEBI:81220
kukoamineA
AC1NSXD9
SCHEMBL16547596
BDBM50240622
DNC013917
C17615
3-(3,4-Dihydroxy-phenyl)-N-[3-(4-{3-[3-(3,4-dihydroxy-phenyl)-propionylamino]-propylamino}-butylamino)-propyl]-propionamide
3-(3,4-dihydroxyphenyl)-N-(3-{[4-({3-[3-(3,4-dihydroxyphenyl)propanamido]propyl}amino)butyl]amino}propyl)propanamide
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
KEGG
Properties
C28H42N4O6
Molar mass 530.67 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Kukoamines are chemicals that are present in some plants including Lycium chinense, potatoes, and tomatoes.[2][3][4] The most prevalent example is kukoamine A; others include kukoamine B, C, and D.[5][6][7]

Chemically, kukoamines are catechols and also dihydrocaffeic acid derivatives of polyamines.[4]

Effect on Health[edit]

They have been linked to reduced blood pressure and can possibly treat sleeping sickness.[8] Kukoamines have also been used in chinese medicine by using the lycium chinense plant.

References[edit]

  1. ^ CID 5318865 from PubChem
  2. ^ Lim, T. K. (2016-02-11). Edible Medicinal and Non-Medicinal Plants: Volume 12 Modified Stems, Roots, Bulbs. Springer. ISBN 9783319260655.
  3. ^ "Kukoamines Found in Potatoes". cabi.org. Retrieved 2017-04-07.
  4. ^ a b Parr, Adrian J.; Mellon, Fred A.; Colquhoun, Ian J.; Davies, Howard V. (2005). "Dihydrocaffeoyl Polyamines (Kukoamine and Allies) in Potato (Solanum tuberosum) Tubers Detected during Metabolite Profiling". Journal of Agricultural and Food Chemistry. 53 (13): 5461. doi:10.1021/jf050298i. PMID 15969534.
  5. ^ CID 10346914 from PubChem, entry for kukoamine B
  6. ^ CID 10052730 from PubChem, entry for kukoamine C
  7. ^ CID 10075692 from PubChem, entry for kukoamine D
  8. ^ Lim, T. K. (2016-02-11). Edible Medicinal and Non-Medicinal Plants: Volume 12 Modified Stems, Roots, Bulbs. Springer. ISBN 9783319260655.