Kurzrock–Miller test

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Kurzrok-Miller in-vitro slide test of sperm-mucus interaction.

The Kurzrok–Miller test is an in-vitro test of sperm–mucus interaction. It consists of establishing an interface between cervical mucus and liquefied semen.[1] It is one of the tests used for investigating infertility.


The test is named after Raphael Kurzrok and Thomas Grier Miller.[2]


  1. Negative test: Spermatozoa congregate on semen side of the interface, but do not penetrate it.
  2. Abnormal: Spermatozoa penetrate the mucus, but rapidly become immobile or acquire shaking movement.
  3. Poor: after penetration, spermatozoa do not progress farther than 500 μm.
  4. Normal: Spermatozoa penetrate the mucus and >90% are motile with definite progression, crossing 3 cm at 30 minutes.[3]

See also[edit]


  1. ^ Mortimer, David (1994). Practical laboratory andrology. New York: Oxford University Press. pp. 186–188. ISBN 9780195065954. 
  2. ^ "Kurzrok-Miller test". Whonamedit?. Retrieved 3 July 2013. 
  3. ^ Padubidri; Daftary (2011). Shaw's Textbook of Gynaecology, 15e. p. 204. ISBN 9788131225486