The Kurzrok–Miller test is an in-vitro test of sperm–mucus interaction. It consists of establishing an interface between cervical mucus and liquefied semen. It is one of the tests used for investigating infertility.
The test is named after Raphael Kurzrok and Thomas Grier Miller.
- Negative test: Spermatozoa congregate on semen side of the interface, but do not penetrate it.
- Abnormal: Spermatozoa penetrate the mucus, but rapidly become immobile or acquire shaking movement.
- Poor: after penetration, spermatozoa do not progress farther than 500 μm.
- Normal: Spermatozoa penetrate the mucus and >90% are motile with definite progression, crossing 3 cm at 30 minutes.