KvLQT3

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KCNQ3
Identifiers
Aliases KCNQ3, BFNC2, EBN2, KV7.3, potassium voltage-gated channel subfamily Q member 3
External IDs OMIM: 602232 MGI: 1336181 HomoloGene: 20949 GeneCards: KCNQ3
Gene location (Human)
Chromosome 8 (human)
Chr. Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for KCNQ3
Genomic location for KCNQ3
Band 8q24.22 Start 132,120,858 bp[1]
End 132,481,019 bp[1]
RNA expression pattern
PBB GE KCNQ3 206573 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204824
NM_004519

NM_152923

RefSeq (protein)

NP_001191753
NP_004510

NP_690887

Location (UCSC) Chr 8: 132.12 – 132.48 Mb Chr 8: 65.99 – 66.29 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kv7.3 (KvLQT3) is a potassium channel protein coded for by the gene KCNQ3.[5]

It is associated with benign familial neonatal epilepsy.

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2).[5]

Interactions[edit]

KvLQT3 has been shown to interact with KCNQ5.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184156 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056258 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: KCNQ3 potassium voltage-gated channel, KQT-like subfamily, member 3". 
  6. ^ Yus-Nájera, E; Muñoz A; Salvador N; Jensen B S; Rasmussen H B; Defelipe J; Villarroel A (2003). "Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation". Neuroscience. United States. 120 (2): 353–64. ISSN 0306-4522. PMID 12890507. doi:10.1016/S0306-4522(03)00321-X. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.