In spring training in 2013, Skipworth competed with Miguel Olivo for a spot on the 25-man roster as a backup catcher to Rob Brantly, the starter, following an injury to Jeff Mathis. Olivo won the role, and Skipworth was optioned to the New Orleans Zephyrs of the Class AAAPacific Coast League before the start of the season. On April 5, the Marlins promoted Skipworth to the major leagues when they placed Casey Kotchman on the disabled list. He was designated for assignment on December 18, 2013. Skipworth played the 2014 season with New Orleans, and became a free agent at the end of the season. He signed with the Cincinnati Reds in the offseason and was a non-roster invitee to 2015 spring training. The Reds called him up to the major leagues on April 13, 2015.