L-iditol 2-dehydrogenase

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L-iditol 2-dehydrogenase
1pl8.jpg
Sorbitol dehydrogenase tetramer, Human
Identifiers
EC number1.1.1.14
CAS number9028-21-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a L-iditol 2-dehydrogenase (EC 1.1.1.14) is an enzyme that catalyzes the chemical reaction

L-iditol + NAD+ ⇌ L-sorbose + NADH + H+

Thus, the two substrates of this enzyme are L-iditol and NAD+, whereas its 3 products are L-sorbose, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-iditol:NAD+ 2-oxidoreductase. Other names in common use include polyol dehydrogenase, sorbitol dehydrogenase, L-iditol:NAD+ 5-oxidoreductase, L-iditol (sorbitol) dehydrogenase, glucitol dehydrogenase, L-iditol:NAD+ oxidoreductase, NAD+-dependent sorbitol dehydrogenase, NAD+-dependent sorbitol dehydrogenase, and NAD+-sorbitol dehydrogenase. This enzyme participates in fructose and mannose metabolism.

Structural studies[edit]

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1K2W, 1PL6, 1PL7, and 1PL8.

References[edit]

  • Bailey JP, Renz C & McGuinness ET (1981). "Sorbitol dehydrogenase from horse liver: purification, characterization and comparative properties". Comp. Biochem. Physiol. 69B: 909–914.
  • Burnell JN, Holmes RS (1983). "Purification and properties of sorbitol dehydrogenase from mouse liver". Int. J. Biochem. 15 (4): 507–11. doi:10.1016/0020-711X(83)90124-6. PMID 6852349.
  • Leissing N, McGuinness ET (1978). "Rapid affinity purification and properties of rat liver sorbitol dehydrogenase". Biochim. Biophys. Acta. 524 (2): 254–61. doi:10.1016/0005-2744(78)90162-6. PMID 667078.
  • Negm FB & Loescher WH (1979). "Detection and Characterization of Sorbitol Dehydrogenase from Apple Callus Tissue". Plant Physiol. 64 (1): 69–73. doi:10.1104/pp.64.1.69. PMC 543026. PMID 16660917.
  • O'Brien MM, Schofield PJ, Edwards MR (1983). "Polyol-pathway enzymes of human brain. Partial purification and properties of sorbitol dehydrogenase". Biochem. J. 211 (1): 81–90. PMC 1154331. PMID 6870831.