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Leukocyte-associated immunoglobulin-like receptor 2
Symbols LAIR2 ; CD306
External IDs OMIM602993 HomoloGene88663 GeneCards: LAIR2 Gene
RNA expression pattern
PBB GE LAIR2 207509 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3904 n/a
Ensembl ENSG00000167618 n/a
UniProt Q6ISS4 n/a
RefSeq (mRNA) NM_002288 n/a
RefSeq (protein) NP_002279 n/a
Location (UCSC) Chr 19:
54.5 – 54.51 Mb
PubMed search [1] n/a

Leukocyte-associated immunoglobulin-like receptor 2 is a protein that in humans is encoded by the LAIR2 gene.[1][2]

The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The function of this protein is unknown, although it is thought to be secreted and may help modulate mucosal tolerance. Two transcript variants encoding different isoforms have been found for this gene.[2]


  1. ^ Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH (Sep 1997). "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes". Immunity 7 (2): 283–90. doi:10.1016/S1074-7613(00)80530-0. PMID 9285412. 
  2. ^ a b "Entrez Gene: LAIR2 leukocyte-associated immunoglobulin-like receptor 2". 

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