LAIR2

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LAIR2
Identifiers
Aliases LAIR2, CD306, leukocyte associated immunoglobulin like receptor 2
External IDs HomoloGene: 88663 GeneCards: LAIR2
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for LAIR2
Genomic location for LAIR2
Band 19q13.42 Start 54,497,879 bp[1]
End 54,510,687 bp[1]
RNA expression pattern
PBB GE LAIR2 207509 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002288
NM_021270

n/a

RefSeq (protein)

NP_002279
NP_067154

n/a

Location (UCSC) Chr 19: 54.5 – 54.51 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Leukocyte-associated immunoglobulin-like receptor 2 is a protein that in humans is encoded by the LAIR2 gene.[3][4]

The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The function of this protein is unknown, although it is thought to be secreted and may help modulate mucosal tolerance. Two transcript variants encoding different isoforms have been found for this gene.[4]

References[edit]

  1. ^ a b c ENSG00000275819, ENSG00000277335, ENSG00000274084 GRCh38: Ensembl release 89: ENSG00000167618, ENSG00000275819, ENSG00000277335, ENSG00000274084 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH (Sep 1997). "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes". Immunity. 7 (2): 283–90. doi:10.1016/S1074-7613(00)80530-0. PMID 9285412. 
  4. ^ a b "Entrez Gene: LAIR2 leukocyte-associated immunoglobulin-like receptor 2". 

Further reading[edit]