Laminin, alpha 2

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LAMA2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LAMA2, LAMM, Laminin, alpha 2, laminin subunit alpha 2
External IDs MGI: 99912 HomoloGene: 37306 GeneCards: LAMA2
Genetically Related Diseases
amyotrophic lateral sclerosis, refractive error[1]
RNA expression pattern
PBB GE LAMA2 213519 s at fs.png

PBB GE LAMA2 216840 s at fs.png

PBB GE LAMA2 205116 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000426
NM_001079823

NM_008481

RefSeq (protein)

NP_000417
NP_001073291

NP_032507.2
NP_032507

Location (UCSC) Chr 6: 128.88 – 129.52 Mb Chr 10: 26.98 – 27.62 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Laminin subunit alpha-2 is a protein that in humans is encoded by the LAMA2 gene.[4][5][6]

Function[edit]

Laminin, an extracellular matrix protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene.[6]

References[edit]

Further reading[edit]

External links[edit]