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LIM and SH3 protein 1
Protein LASP1 PDB 1zfo.png
PDB rendering based on 1zfo.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols LASP1 ; Lasp-1; MLN50
External IDs OMIM602920 MGI109656 HomoloGene4480 GeneCards: LASP1 Gene
RNA expression pattern
PBB GE LASP1 200618 at tn.png
More reference expression data
Species Human Mouse
Entrez 3927 16796
Ensembl ENSG00000002834 ENSMUSG00000038366
UniProt Q14847 Q61792
RefSeq (mRNA) NM_001271608 NM_010688
RefSeq (protein) NP_001258537 NP_034818
Location (UCSC) Chr 17:
38.87 – 38.92 Mb
Chr 11:
97.8 – 97.84 Mb
PubMed search [1] [2]

LIM and SH3 domain protein 1 is a protein that in humans is encoded by the LASP1 gene.[1][2]

This gene encodes a member of a LIM protein subfamily which is characterized by a LIM motif and a domain of Src homology region 3. This protein functions as an actin-binding protein and possibly in cytoskeletal organization.[2]


LASP1 has been shown to interact with Zyxin.[3]


  1. ^ Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC (Jan 1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17". Genomics 28 (3): 367–76. doi:10.1006/geno.1995.1163. PMID 7490069. 
  2. ^ a b "Entrez Gene: LASP1 LIM and SH3 protein 1". 
  3. ^ Li, Bo; Zhuang Lei; Trueb Beat (May 2004). "Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1". J. Biol. Chem. (United States) 279 (19): 20401–10. doi:10.1074/jbc.M310304200. ISSN 0021-9258. PMID 15004028. 

Further reading[edit]