LATS1

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LATS1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LATS1, WARTS, wts, large tumor suppressor kinase 1
External IDs MGI: 1333883 HomoloGene: 55843 GeneCards: 9113
RNA expression pattern
PBB GE LATS1 219813 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270519
NM_004690

NM_010690

RefSeq (protein)

NP_001257448.1
NP_004681.1

NP_034820.1

Location (UCSC) Chr 6: 149.66 – 149.72 Mb Chr 10: 7.68 – 7.72 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase LATS1 is an enzyme that in humans is encoded by the LATS1 gene.[1][2][3]

It has been associated with the Hippo signaling pathway.[4]

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.[3]

Interactions[edit]

LATS1 has been shown to interact with Zyxin[5] and Cdk1.[1]

References[edit]

  1. ^ a b Tao W, Zhang S, Turenchalk GS, Stewart RA, St John MA, Chen W, Xu T (February 1999). "Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity". Nat Genet 21 (2): 177–81. doi:10.1038/5960. PMID 9988268. 
  2. ^ Iida S, Hirota T, Morisaki T, Marumoto T, Hara T, Kuninaka S, Honda S, Kosai K, Kawasuji M, Pallas DC, Saya H (July 2004). "Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function". Oncogene 23 (31): 5266–74. doi:10.1038/sj.onc.1207623. PMID 15122335. 
  3. ^ a b "Entrez Gene: LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila)". 
  4. ^ Hao Y, Chun A, Cheung K, Rashidi B, Yang X (February 2008). "Tumor suppressor LATS1 is a negative regulator of oncogene YAP". J. Biol. Chem. 283 (9): 5496–509. doi:10.1074/jbc.M709037200. PMID 18158288. 
  5. ^ Hirota, T; Morisaki T; Nishiyama Y; Marumoto T; Tada K; Hara T; Masuko N; Inagaki M; Hatakeyama K; Saya H (May 2000). "Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor". J. Cell Biol. (UNITED STATES) 149 (5): 1073–86. doi:10.1083/jcb.149.5.1073. ISSN 0021-9525. PMC 2174824. PMID 10831611. 

Further reading[edit]